Effect of Type 1 Diabetes and Age on Hydroxyapatite Concentration and Elastic Modulus in the Cortical Bone

Michael, Eric; Ea, Davy; Jasiuk, Iwona

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https://hdl.handle.net/2142/99974 Copy

Description

Title

Effect of Type 1 Diabetes and Age on Hydroxyapatite Concentration and Elastic Modulus in the Cortical Bone

Author(s)

• Michael, Eric
• Ea, Davy
• Jasiuk, Iwona

Contributor(s)

Dobrucki, Lawrence W

Issue Date

2018-04

Keyword(s)

• Bioengineering
• Imaging
• Mechanical testing
• Bone mineral content
• Elastic modulus

Abstract

It is common for patients with type 1 diabetes to have marked reductions in body strength and ability to perform physical activities. These markers for physical strength are also known to change with age. Type 1 diabetes is correlated with fatigue but is not known to be related to changes in the cortical bone. In this study, we hypothesize that type 1 diabetes causes a reduction in the concentration of hydroxyapatite (HA) and in the elastic modulus of the cortical bone. Moreover, we predict that adult-aged bones will exhibit greater hydroxyapatite concentrations and elastic moduli than younger bones. We perform this study on Lewis rats with and without type 1 diabetes and at different ages. The tibiae and femora of each rat have been separated from the body and isolated for medical imaging. We determine the hydroxyapatite content of the bones by analyzing images collected with a microCT scanner and comparing the radiodensities of these bones to phantoms of known hydroxyapatite content. Elastic moduli data are also collected by performing a mechanical bending test on each bone. Through our experimental data, we hope to determine how type 1 diabetes and age, when considered separately, affect the parameters of interest.

Type of Resource

image

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http://hdl.handle.net/2142/99974

Copyright and License Information

• Copyright 2018 Eric Michael
• Copyright 2018 Davy Ea
• Copyright 2018 Iwona Jasiuk

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