The crystallinity of naproxen in solid combinations with maltoheptaose was assessed by differential scanning calorimetry supported by X-ray diffractometry. Cogrinding induced a decrease of drug crystallinity to an extent depending on the grinding time. Interactions in solutions between naproxen and maltoheptaose were studied by fluorescence spectroscopy, phase-solubilirty analysis and molecular modelling. Maltoheptaose can wrap up naproxen, taking on a cyclic conformation and forming a pseudo inclusion complex.
INTERACTIONS BETWEEN NAPROXEN AND MALTOHEPTAOSE, THJE NON-CYCLIC ANALOG OF BETA-CYCLODEXTRIN / G. BETTINETTI; P. MURA; F. MELANI; F. GIORDANO; M. RILLOSI. - In: JOURNAL OF INCLUSION PHENOMENA AND MOLECULAR RECOGNITION IN CHEMISTRY. - ISSN 0923-0750. - STAMPA. - 25:(1996), pp. 327-338.
INTERACTIONS BETWEEN NAPROXEN AND MALTOHEPTAOSE, THJE NON-CYCLIC ANALOG OF BETA-CYCLODEXTRIN
MURA, PAOLA ANGELA;MELANI, FABRIZIO;
1996
Abstract
The crystallinity of naproxen in solid combinations with maltoheptaose was assessed by differential scanning calorimetry supported by X-ray diffractometry. Cogrinding induced a decrease of drug crystallinity to an extent depending on the grinding time. Interactions in solutions between naproxen and maltoheptaose were studied by fluorescence spectroscopy, phase-solubilirty analysis and molecular modelling. Maltoheptaose can wrap up naproxen, taking on a cyclic conformation and forming a pseudo inclusion complex.
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