WEKO3
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ELOVL fatty acid elongase 6 (Elovl6) is responsible for converting C16 saturated and monounsaturated fatty acids (FAs) into C18 species. We have previously shown that Elovl6 contributes to obesity‐induced insulin resistance by modifying hepatic C16/C18‐related FA composition.\nApproach and Results\nTo define the precise molecular mechanism by which hepatic Elovl6 affects energy homeostasis and metabolic disease, we generated liver‐specific Elovl6 knockout (LKO) mice. Unexpectedly, LKO mice were not protected from high‐fat diet–induced insulin resistance. Instead, LKO mice exhibited higher insulin sensitivity than controls when consuming a high‐sucrose diet (HSD), which induces lipogenesis. Hepatic patatin‐like phospholipase domain‐containing protein 3 (Pnpla3) expression was down‐regulated in LKO mice, and adenoviral Pnpla3 restoration reversed the enhancement in insulin sensitivity in HSD‐fed LKO mice. 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Consistent with this, liver‐specific Elovl6 deletion in ob/ob mice reduced both hepatic ceramide(d18:1/18:0) and PP2A activity and ameliorated insulin resistance.\nConclusions\nOur study demonstrates the key role of hepatic Elovl6 in the regulation of the acyl‐chain composition of ceramide and that C18:0‐ceramide is a potent regulator of hepatic insulin signaling linked to Pnpla3‐mediated NAFLD.", "subitem_description_type": "Abstract"}]}, "item_5_publisher_27": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "American Association for the Study of Liver Diseases"}, {"subitem_publisher": "Wiley"}]}, "item_5_relation_10": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "31529722", "subitem_relation_type_select": "PMID"}}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1002/hep.30953", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2019 by the American Association for the Study of Liver Disease"}, {"subitem_rights": "This is the peer reviewed version of the following article: Hepatology 71(5):1609-1625, which has been published in final form at https://doi.org/10.1002/hep.30953. 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Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl‐Chain Length and Hepatic Insulin Sensitivity in Mice
http://hdl.handle.net/2241/00161437
http://hdl.handle.net/2241/0016143784fd590e-5331-49e1-8367-508302059e50
名前 / ファイル | ライセンス | アクション |
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HEP_71-5-1609 (7.4 MB)
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Item type | Journal Article(1) | |||||||||||||||||||||||
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公開日 | 2020-09-23 | |||||||||||||||||||||||
タイトル | ||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||
タイトル | Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl‐Chain Length and Hepatic Insulin Sensitivity in Mice | |||||||||||||||||||||||
言語 | ||||||||||||||||||||||||
言語 | eng | |||||||||||||||||||||||
資源タイプ | ||||||||||||||||||||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
タイプ | journal article | |||||||||||||||||||||||
著者 |
松坂, 賢
× 松坂, 賢
WEKO
204843
× 會田, 雄一× 岩﨑, 仁× 矢藤, 繁× 鈴木, 浩明× 武内, 謙憲
WEKO
204488
× 矢作, 直也× 宮本, 崇史
WEKO
204920
× 関谷, 元博× 高橋, 智× 島野, 仁× Kuba, Motoko× Koyasu, Saori× Yamamoto, Yuta× Motomura, Kaori× Arulmozhiraja, Sundaram× Ohno, Hiroshi× Sharma, Rahul× Shimura, Takuya× Okajima, Yuka× Han, Song‐iee× Mizunoe, Yuhei× Osaki, Yoshinori× Sone, Hirohito× Nakagawa, Yoshimi× Ema, Masatsugu× Tokiwa, Hiroaki |
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抄録 | ||||||||||||||||||||||||
内容記述タイプ | Abstract | |||||||||||||||||||||||
内容記述 | Background and Aims Dysfunctional hepatic lipid metabolism is a cause of nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disorder worldwide, and is closely associated with insulin resistance and type 2 diabetes. ELOVL fatty acid elongase 6 (Elovl6) is responsible for converting C16 saturated and monounsaturated fatty acids (FAs) into C18 species. We have previously shown that Elovl6 contributes to obesity‐induced insulin resistance by modifying hepatic C16/C18‐related FA composition. Approach and Results To define the precise molecular mechanism by which hepatic Elovl6 affects energy homeostasis and metabolic disease, we generated liver‐specific Elovl6 knockout (LKO) mice. Unexpectedly, LKO mice were not protected from high‐fat diet–induced insulin resistance. Instead, LKO mice exhibited higher insulin sensitivity than controls when consuming a high‐sucrose diet (HSD), which induces lipogenesis. Hepatic patatin‐like phospholipase domain‐containing protein 3 (Pnpla3) expression was down‐regulated in LKO mice, and adenoviral Pnpla3 restoration reversed the enhancement in insulin sensitivity in HSD‐fed LKO mice. Lipidomic analyses showed that the hepatic ceramide(d18:1/18:0) content was lower in LKO mice, which may explain the effect on insulin sensitivity. Ceramide(d18:1/18:0) enhances protein phosphatase 2A (PP2A) activity by interfering with the binding of PP2A to inhibitor 2 of PP2A, leading to Akt dephosphorylation. Its production involves the formation of an Elovl6–ceramide synthase 4 (CerS4) complex in the endoplasmic reticulum and a Pnpla3–CerS4 complex on lipid droplets. Consistent with this, liver‐specific Elovl6 deletion in ob/ob mice reduced both hepatic ceramide(d18:1/18:0) and PP2A activity and ameliorated insulin resistance. Conclusions Our study demonstrates the key role of hepatic Elovl6 in the regulation of the acyl‐chain composition of ceramide and that C18:0‐ceramide is a potent regulator of hepatic insulin signaling linked to Pnpla3‐mediated NAFLD. |
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書誌情報 |
en : Hepatology 巻 71, 号 5, p. 1609-1625, 発行日 2020-05 |
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ISSN | ||||||||||||||||||||||||
収録物識別子タイプ | ISSN | |||||||||||||||||||||||
収録物識別子 | 0270-9139 | |||||||||||||||||||||||
書誌レコードID | ||||||||||||||||||||||||
収録物識別子タイプ | NCID | |||||||||||||||||||||||
収録物識別子 | AA10620324 | |||||||||||||||||||||||
DOI | ||||||||||||||||||||||||
識別子タイプ | DOI | |||||||||||||||||||||||
関連識別子 | 10.1002/hep.30953 | |||||||||||||||||||||||
PubMed番号 | ||||||||||||||||||||||||
識別子タイプ | PMID | |||||||||||||||||||||||
関連識別子 | 31529722 | |||||||||||||||||||||||
権利 | ||||||||||||||||||||||||
権利情報 | © 2019 by the American Association for the Study of Liver Disease | |||||||||||||||||||||||
権利 | ||||||||||||||||||||||||
権利情報 | This is the peer reviewed version of the following article: Hepatology 71(5):1609-1625, which has been published in final form at https://doi.org/10.1002/hep.30953. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | |||||||||||||||||||||||
著者版フラグ | ||||||||||||||||||||||||
値 | author | |||||||||||||||||||||||
出版者 | ||||||||||||||||||||||||
出版者 | American Association for the Study of Liver Diseases | |||||||||||||||||||||||
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出版者 | Wiley |