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非選択的エンドセリン受容体拮抗薬は、アポE欠損マウスの食餌性高コレステロール血症と動脈硬化病変を抑制する。動脈硬化発生におけるエンドセリンB受容体を介したET-1作用の重要性について
http://hdl.handle.net/2241/6040
http://hdl.handle.net/2241/6040d1c2eed5-1a17-4c3e-9de6-dd3a5449bda9
Item type | Thesis or Dissertation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2007-07-25 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Non-selective endothelin receptor antagonist reduces diet-induced hypercholesterolemia and atherosclerosis in apolipoprotein edeficient mice. ET-1 effect through the ET[B] receptor plays an important role in atherogenesis | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 非選択的エンドセリン受容体拮抗薬は、アポE欠損マウスの食餌性高コレステロール血症と動脈硬化病変を抑制する。動脈硬化発生におけるエンドセリンB受容体を介したET-1作用の重要性について | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_db06 | |||||
タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
岩佐, 敏
× 岩佐, 敏 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Evidence is mounting that endothelin(ET)-1 has proatherogenic properties.This is supported by finding that selective ETA receptor antagonists reduce atherosclerotic immunoreactivity of ET-1 and ETB receptors in human and mouse atherosclerotic lesions.To examine additional effects of ETB receptor antaagonism on atherogenesis,we investigated the choronic effect of the nonselecive ETA/ETB receptor antagonist SB209670 on the development of atherosclerosis in apolipoprotein E(apoE)-deficient mice.94 male mice(10weeks of age)were randomly divided into four groups:Mice fed a Western-type diet or a chow diet with SB209670 treatment(10mg/kg/day)or placebo for 12 weeks.In mice fed the Western-diet,but not in mice fed the chow diet, treatment with SB209670 signigicantly attenuated the increase of plasma total cholesterol level predominantly in very low density lipoprotein and ... | |||||
言語 | en | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Includes supplementary treatises | |||||
言語 | en | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Includes bibliographical references | |||||
言語 | en | |||||
書誌情報 |
発行日 2000 |
|||||
取得学位 | ||||||
学位名 | 博士(医学) | |||||
取得学位 | ||||||
学位名 | Doctor of Philosophy in Medical Sciences | |||||
学位授与大学 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 12102 | |||||
言語 | ja | |||||
学位授与機関名 | 筑波大学 | |||||
言語 | en | |||||
学位授与機関名 | University of Tsukuba | |||||
学位授与年度 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 1999 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2000-03-24 | |||||
報告番号 | ||||||
学位授与番号 | 甲第2375号 |