The development of a new class of C-5' substituted cinchona alkaloid derivatives as efficient organocatalysts
Citation:
Carole Palacio, 'The development of a new class of C-5' substituted cinchona alkaloid derivatives as efficient organocatalysts', [thesis], Trinity College (Dublin, Ireland). School of Chemistry, 2013, pp 343Download Item:
Palacio TCD THESIS 10151 The development.pdf (PDF) 134.3Mb
Abstract:
Over the past three decades, the synthesis of enantiomerically pure products became a
major concern in modem research. In this context, organocatalysis has emerged as a viable method and interest in this field has intensified rapidly. In particular, cinchona alkaloids - incorporating two functionalities capable of the synergestic activation of two components of a reaction in a close and chiral environment - appeared as a valuable material in new organocatalysts design. Various cinchona alkaloid derivatives have been demonstrated to be capable of the bifunctional catalysis of a number of asymmetric reactions involving the addition of an acidic pronucleophile to an electrophile incorporating hydrogen-bond accepting functionality.
Author: Palacio, Carole
Advisor:
Connon, StephenQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of ChemistryNote:
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Chemistry, Ph.D., Ph.D. Trinity College Dublin.Licences: