Abstract:
The cytotoxicity of three Stenocarpella maydis metabolites (diplodiatoxin, dipmatol and
diplonine) was investigated on Neuro-2a, CHO-K1 and MDBK cell lines. Diplodiatoxin was
the most cytotoxic followed by dipmatol. Conversely, diplonine was not cytotoxic. Diplodiatoxin
and dipmatol affected mitochondrial succinate dehydrogenase (MTT assay) and
the overall viability of cells as assessed in real-time (xCELLigence assay). The results obtained
so far indicate that diplodiatoxin and dipmatol exert their toxicity possibly via the
necrotic cell death pathway.
