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Article (Scientific journals)
Coexpression of cytokeratin and vimentin in eutopic endometrium and endometriosis throughout the menstrual cycle: evaluation by a computerized method.
NISOLLE, Michelle; Casanas-Roux, Françoise; Donnez, Jacques
1995In Fertility and Sterility, 64 (1), p. 69-75
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Abstract :
[en] Objectives: To evaluate quantitatively cytokeratin and vimentin staining in glandular and stromal cells of eutopic and ectopic endometrium. DESIGN: The investigation of cytokeratin and vimentin was carried out using the new computerized technology of image analysis. SETTING: University Hospital, Department of Gynecology. PATIENTS: Biopsies were taken from patients undergoing a laparoscopy for infertility (29 endometrial biopsies and 31 biopsies of peritoneal endometriosis). None of them were treated. RESULTS: Cyclic variations of cytokeratin and vimentin staining were noted in eutopic endometrium. The cytokeratin and vimentin staining pattern consistently was lower in ectopic endometrium than in eutopic endometrium. CONCLUSIONS: Endometriotic epithelial and stromal cells undergo a complex program of differentiation giving them histochemical characteristics similar to those observed in endometrium. Such a concomitant expression of antigenicity indicates their close relationship with their mesodermal müllerian origin.
Disciplines :
Reproductive medicine (gynecology, andrology, obstetrics)
Author, co-author :
NISOLLE, Michelle ;  Centre Hospitalier Universitaire de Liège - CHU > Gynécologie-Obstétrique CHR
Casanas-Roux, Françoise
Donnez, Jacques
Language :
English
Title :
Coexpression of cytokeratin and vimentin in eutopic endometrium and endometriosis throughout the menstrual cycle: evaluation by a computerized method.
Publication date :
1995
Journal title :
Fertility and Sterility
ISSN :
0015-0282
eISSN :
1556-5653
Publisher :
Elsevier, New York, United States - New York
Volume :
64
Issue :
1
Pages :
69-75
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 16 November 2011

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