Article (Scientific journals)
Genome scan for familial abdominal aortic aneurysm using sex and family history as covariates suggests genetic heterogeneity and identifies linkage to chromosome 19q13.
Shibamura, Hidenori; Olson, Jane M; van Vlijmen-Van Keulen, Clarissa et al.
2004In Circulation, 109 (17), p. 2103-8
Peer Reviewed verified by ORBi
 

Files


Full Text
NS26.pdf
Publisher postprint (261.84 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Adult; Aged; Aortic Aneurysm, Abdominal/epidemiology/genetics; Chromosomes, Human/genetics; Chromosomes, Human, Pair 19/genetics; Chromosomes, Human, Pair 4/genetics; Female; Genetic Heterogeneity; Genetic Predisposition to Disease; Genotype; Humans; Lod Score; Male; Microsatellite Repeats; Middle Aged; Phenotype; Polymerase Chain Reaction
Abstract :
[en] BACKGROUND: Abdominal aortic aneurysm (AAA) is a relatively common disease, with 1% to 2% of the population harboring aneurysms. Genetic risk factors are likely to contribute to the development of AAAs, although no such risk factors have been identified. METHODS AND RESULTS: We performed a whole-genome scan of AAA using affected-relative-pair (ARP) linkage analysis that includes covariates to allow for genetic heterogeneity. We found strong evidence of linkage (logarithm of odds [LOD] score=4.64) to a region near marker D19S433 at 51.88 centimorgans (cM) on chromosome 19 with 36 families (75 ARPs) when including sex and the number of affected first-degree relatives of the proband (N(aff)) as covariates. We then genotyped 83 additional families for the same markers and typed additional markers for all families and obtained a LOD score of 4.75 (P=0.00014) with sex, N(aff), and their interaction as covariates near marker D19S416 (58.69 cM). We also identified a region on chromosome 4 with a LOD score of 3.73 (P=0.0012) near marker D4S1644 using the same covariate model as for chromosome 19. CONCLUSIONS: Our results provide evidence for genetic heterogeneity and the presence of susceptibility loci for AAA on chromosomes 19q13 and 4q31.
Disciplines :
Surgery
Author, co-author :
Shibamura, Hidenori
Olson, Jane M
van Vlijmen-Van Keulen, Clarissa
Buxbaum, Sarah G
Dudek, Doreen M
Tromp, Gerard
Ogata, Toru
Skunca, Magdalena
SakalihasanN, Natzi ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie cardio-vasculaire
Pals, Gerard
MacKean, Gerald L
Defawe, Olivier
VERLOES, Alain ;  Centre Hospitalier Universitaire de Liège - CHU > Génétique
Arthur, Claudette
Lossing, Alan G
Burnett, Marjorie
Sueda, Taijiro
Kuivaniemi, Helena
More authors (9 more) Less
Language :
English
Title :
Genome scan for familial abdominal aortic aneurysm using sex and family history as covariates suggests genetic heterogeneity and identifies linkage to chromosome 19q13.
Publication date :
2004
Journal title :
Circulation
ISSN :
0009-7322
eISSN :
1524-4539
Publisher :
Lippincott Williams & Wilkins, Hagerstown, United States - Maryland
Volume :
109
Issue :
17
Pages :
2103-8
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 13 April 2012

Statistics


Number of views
84 (4 by ULiège)
Number of downloads
266 (2 by ULiège)

Scopus citations®
 
115
Scopus citations®
without self-citations
84
OpenCitations
 
107

Bibliography


Similar publications



Contact ORBi