Article (Scientific journals)
L'adiponectine: une nouvelle adipocytokine.
Lebas, Eglantine; Paquot, Nicolas; Scheen, André
2003In Revue Médicale de Liège, 58 (9), p. 554-8
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Keywords :
Adiponectin; Adipose Tissue/physiopathology; Coronary Artery Disease/physiopathology; Humans; Insulin Resistance/physiology; Intercellular Signaling Peptides and Proteins; Proteins/physiology; Receptors, Cytoplasmic and Nuclear/metabolism; Thiazolidinediones/metabolism; Tumor Necrosis Factor-alpha/metabolism
Abstract :
[en] Adipose tissue is not simply a store of excess energy, but also secretes a variety of proteins into circulating blood that influence systemic metabolism. These include tumor necrosis factor (TNF-alpha), plasminogen activator inhibitor type 1 (PAI-1), leptin, resistine and adiponectin. These are collectively known as adipocytokines. Adiponectin (also referred to as AdipoQ, Acrp 30, apM1 or GBP28) is a novel adipose-specific protein. A recent genome study mapped a susceptibility locus for type 2 diabetes and the metabolic syndrome on chromosome 3q27, where the adiponectin gene is located. Adiponectin is a peculiar adipocytokine because in contrast to the markedly increased levels of many others, as leptin or TNF-alpha, its level is reduced in obesity and type 2 diabetes. The administration of thiazolidinediones, which are synthetic PPARs-gamma ligands, significantly increases the plasma adiponectin concentrations, an effect that could improve insulin sensitivity. Thus, the administration of adiponectin may provide a novel treatment modality for insulin resistance and type 2 diabetes.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Lebas, Eglantine ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatologie
Paquot, Nicolas ;  Centre Hospitalier Universitaire de Liège - CHU > Diabétologie,nutrition, maladies métaboliques
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Language :
French
Title :
L'adiponectine: une nouvelle adipocytokine.
Alternative titles :
[en] Adiponectin: a new adipocytokine
Publication date :
2003
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Volume :
58
Issue :
9
Pages :
554-8
Peer reviewed :
Peer reviewed
Additional URL :
Available on ORBi :
since 08 May 2009

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