Article (Scientific journals)
Specific IgE against Staphylococcus aureus enterotoxins: An independent risk factor for asthma
Bachert, C.; Van Steen, Kristel; Zhang, N. et al.
2012In Journal of Allergy and Clinical Immunology, 130 (2), p. 376-381.e8
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Keywords :
Asthma; FEV 1; IgE; Staphylococcus aureus
Abstract :
[en] Background: The role of IgE in patients with severe asthma is not fully understood. Objective: We sought to investigate whether IgE to Staphylococcus aureus enterotoxins might be relevant to disease severity in adult asthmatic patients. Methods: Specific IgE antibody concentrations in serum against enterotoxins, grass pollen (GP), and house dust mite allergens and total IgE levels were measured in adult cohorts of 69 control subjects, 152 patients with nonsevere asthma, and 166 patients with severe asthma. Severe asthma was defined as inadequately controlled disease despite high-dose inhaled corticosteroids plus at least 2 other controller therapies, including oral steroids. Results: Enterotoxin IgE positivity was significantly greater in patients with severe asthma (59.6%) than in healthy control subjects (13%, P < .001). Twenty-one percent of patients with severe asthma with enterotoxin IgE were considered nonatopic. Logistic regression analyses demonstrated significantly increased risks for enterotoxin IgE-positive subjects to have any asthma (OR, 7.25; 95% CI, 2.7-19.1) or severe asthma (OR, 11.09; 95% CI, 4.1-29.6) versus enterotoxin IgE-negative subjects. The presence of GP or house dust mite IgE antibodies was not associated with either significantly increased risk for asthma or severity. Oral steroid use and hospitalizations were significantly increased in patients with enterotoxin IgE and nonatopic asthma. GP IgE was associated with a higher FEV 1 percent predicted value, and enterotoxin IgE was associated with a lower FEV 1 percent predicted value. Conclusions: Staphylococcal enterotoxin IgE antibodies, but not IgE against inhalant allergens, are risk factors for asthma severity. We hypothesize that the presence of enterotoxin IgE in serum indicates the involvement of staphylococcal superantigens in the pathophysiology of patients with severe asthma. © 2012 American Academy of Allergy, Asthma & Immunology.
Disciplines :
Immunology & infectious disease
Author, co-author :
Bachert, C.;  Upper Airway Research Laboratory (URL), Ghent University Hospital, Ghent, Belgium
Van Steen, Kristel  ;  Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Bioinformatique
Zhang, N.;  Upper Airway Research Laboratory (URL), Ghent University Hospital, Ghent, Belgium
Holtappels, G.;  Upper Airway Research Laboratory (URL), Ghent University Hospital, Ghent, Belgium
Cattaert, Tom ;  Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Bioinformatique
Maus, Bärbel ;  Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Bioinformatique
Buhl, R.;  Pulmonary Department, Mainz University Hospital, Mainz, Germany
Taube, C.;  Pulmonary Department, Mainz University Hospital, Mainz, Germany, Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
Korn, S.;  Pulmonary Department, Mainz University Hospital, Mainz, Germany
Kowalski, M.;  Department of Allergy, Immunology and Rheumatology, Medical University of Lodz, Lódź, Poland
Bousquet, J.;  University Hospital and INSERM 1080, Montpellier, Montpellier, France
Howarth, P.;  Clinical and Experimental Sciences, Faculty of Medicine, Southampton University and National Institute of Health Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton, United Kingdom
Language :
English
Title :
Specific IgE against Staphylococcus aureus enterotoxins: An independent risk factor for asthma
Publication date :
2012
Journal title :
Journal of Allergy and Clinical Immunology
ISSN :
0091-6749
eISSN :
1097-6825
Publisher :
Mosby, United States - Missouri
Volume :
130
Issue :
2
Pages :
376-381.e8
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 28 August 2012

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