Comparison of Sublingual and Oral Prazepam in Normal Subjects. I. Clinical Data

[en] Five normal volunteers received at a 2-week interval a single dose of sublingual or oral prazepam in double-blind and cross-over conditions. All subjects completed a battery of 15 visual analogue scales before drug intake and 7.5, 15, 22.5, 30, 45, 60, 90 min, 2, 3, 5, 6, 7, 8, 9, 10 and 24 h following intake whereas a computerized assessment of vigilance (reaction time) was performed before intake, 15, 30, 60 min, 2, 3, 6, 8, 10 h following intake. Subjects rated themselves significantly more feeble, clumsy, lethargic, and incompetent following sublingual as compared to oral prazepam while a trend in the same direction was noted for the adjectives muzzy and mentally slow. In contrast, reaction time did not exhibit significantly different changes over time between the two forms. These results suggest a subjectively more rapid onset of activity following sublingual compared to oral prazepam.

Disciplines :

Psychiatry
Neurology

Author, co-author :

Ansseau, Marc ; Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale

von Frenckell, Rémy ; Université de Liège - ULiège > Psychiatrie et psychologie médicale

Jacqmin, Philippe; Université Catholique de Louvain - UCL

Language :

English

Title :

Comparison of Sublingual and Oral Prazepam in Normal Subjects. I. Clinical Data

Publication date :

1987

Journal title :

Neuropsychobiology

ISSN :

0302-282X

eISSN :

1423-0224

Publisher :

Karger, Basel, Switzerland

Volume :

Issue :

Pages :

77-82

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 30 June 2020

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Bibliography

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