Article (Scientific journals)
A sulfonylthiourea (BM 20) related to torasemide: a new loop diuretic with relative potassium-sparing properties
Masereel, B.; Schynts, M.; Krzesinski, Jean-Marie et al.
1993In Journal of Pharmacy and Pharmacology, 45, p. 720-724
Peer Reviewed verified by ORBi
 

Files


Full Text
68.pdf
Publisher postprint (363.03 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
diuretic properties; sulphonylthiourea; torasemide
Abstract :
[en] A series of sulphonylthioureas related to torasemide, a high ceiling loop diuretic, were synthesized and found to inhibit the Na+ 2Cl- K+ co-transporter of the thick ascending limb of the loop of Henlé. Their diuretic properties were studied (30 mg kg-1) after oral administration to rats. Lipophilic derivatives very active in-vitro, were found inactive orally and intraperitoneally in rats. The four most active compounds were examined for their dose-dependent diuresis. Three of them showed a potency, water and electrolyte excretion similar to torasemide. The fourth molecule, a sulphonylthiourea (BM 20), exhibited relative potassium-sparing properties and a minimal diuretic dose of 0.001 mg kg-1, 200 times lower than torasemide.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Masereel, B.
Schynts, M.
Krzesinski, Jean-Marie ;  Université de Liège - ULiège > Département des sciences cliniques > Néphrologie
Pirotte, Bernard ;  Université de Liège - ULiège > Département de pharmacie > Chimie pharmaceutique
Rorive, Georges ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Delarge, J.
Language :
English
Title :
A sulfonylthiourea (BM 20) related to torasemide: a new loop diuretic with relative potassium-sparing properties
Publication date :
1993
Journal title :
Journal of Pharmacy and Pharmacology
ISSN :
0022-3573
eISSN :
2042-7158
Publisher :
Pharmaceutical Press, London, United Kingdom
Volume :
45
Pages :
720-724
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 07 December 2009

Statistics


Number of views
64 (5 by ULiège)
Number of downloads
2 (1 by ULiège)

Scopus citations®
 
16
Scopus citations®
without self-citations
8
OpenCitations
 
7

Bibliography


Similar publications



Contact ORBi