Microsatellite mapping of  a major determinant of White Heifer Disease: the bovine roan locus

[en] In the Belgian Blue Cattle breed, coat color variation is mainly under the influence of a single autosomal locus, the roan locus, characterized by a pair of codominant alleles: r + (black) and R (white). Heterozygous r + R animals have intermingled black and white hairs, yielding the ``blue'' phenotype typical of the breed. Major interest for the roan locus stems from its pleiotropic effect on fertility, owing to the critical role of the R allele in the determinism of White Heifer Disease. We describe the linkage mapping of the roan locus to bovine Chromosome (Chr) 5, in the interval between microsatellite markers BPI and AGLA293, with an associated lodscore of 11.2. Moreover, we map a candidate gene, the Steel locus coding for the mast cell growth factor, to bovine Chr 5.

Disciplines :

Veterinary medicine & animal health

Author, co-author :

Charlier, Carole ; Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale

Denys, B.

Belanche, J. I.

Coppieters, Wouter ; Université de Liège - ULiège > Département de productions animales > Département de productions animales

Grobet, L.

Mni, Myriam ; Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale

Womack, J.

Hanset, R.

Georges, Michel ; Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale

Language :

English

Title :

Microsatellite mapping of a major determinant of White Heifer Disease: the bovine roan locus

Publication date :

1996

Journal title :

Mammalian Genome

ISSN :

0938-8990

eISSN :

1432-1777

Publisher :

Springer Verlag, New York, United States - New York

Volume :

Pages :

138-142

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 04 January 2010

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Bibliography

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