Article (Scientific journals)
IBD mapping of recessive traits in livestock: application to map the bovine syndactyly locus to chromosome 15
Charlier, Carole; Farnir, Frédéric; Berzi, P. et al.
1996In Genome Research, 6, p. 580-589
Peer Reviewed verified by ORBi
 

Files


Full Text
CharlierC-GenResearch-1996.pdf
Publisher postprint (2.89 MB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Abstract :
[en] Twelve animals affected with syndactyly or mulefoot were sampled in the Dutch black-and-white cattle population. Analysis of the pedigree data reveal that all of these individuals traced back to a single acknowledged carrier founder individual. Between seven and nine generations separated the founder from its 12 affected descendents. The 12 affected offspring were genotyped for a battery of 213 microsatellites spanning the 29 bovine autosomes. The resulting genotypes were analyzed using a maximum likelihood approach searching for shared homozygous haplotypes among affected individuals. Three candidate regions for the syndactyly locus emerged from this initial screening. syndactyly was shown to map to one of these candidate regions on chromosome 15 by genotyping 29 additional individuals linking founder and affected offspring and performing a conventional linkage analysis with the LINKAGE programs. This study illustrates the potential of identity-by-descent mapping in livestock populations.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Charlier, Carole  ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Farnir, Frédéric  ;  Université de Liège - ULiège > Département de productions animales > Biostatistique, économie, sélection animale
Berzi, P.
Vanmanshoven, P.
Brouwers, B.
Georges, Michel  ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Language :
English
Title :
IBD mapping of recessive traits in livestock: application to map the bovine syndactyly locus to chromosome 15
Publication date :
1996
Journal title :
Genome Research
ISSN :
1088-9051
eISSN :
1549-5469
Publisher :
Cold Spring Harbor Laboratory Press, Cold Spring Harbor, United States - New York
Volume :
6
Pages :
580-589
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 04 January 2010

Statistics


Number of views
90 (3 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
48
Scopus citations®
without self-citations
39
OpenCitations
 
30

Bibliography


Similar publications



Contact ORBi