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Article (Scientific journals)
Substance P-induced histamine release from human basophils, skin and lung fragments: effect of nedocromil sodium and theophylline.
Louis, Renaud; Radermecker, Maurice
1990In International Archives of Allergy and Applied Immunology, 92 (4), p. 329-33
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Keywords :
Adult; Anti-Inflammatory Agents, Non-Steroidal/pharmacology; Basophils/metabolism; Female; Histamine Release/drug effects; Humans; Lung/secretion; Male; Nedocromil; Quinolones/pharmacology; Skin/secretion; Substance P/pharmacology; Theophylline/pharmacology
Abstract :
[en] We compared histamine release induced by substance P with those obtained with classical secretagogues on human basophils, lung and skin fragments. We also tested the capacity of nedocromil sodium and theophylline to inhibit histamine release in these 3 experimental models. Substance P (10(-4) M) caused a noncytotoxic histamine release (about 10% of total) from basophils, lung and skin fragments. Substance P-induced histamine release was always smaller than that obtained with optimal doses of anti-IgE, formyl-methionine phenylalanine or compound 48/80. Nedocromil sodium did not prevent secretagogue-induced histamine release from basophils or sliced skin. In contrast, it significantly inhibited anti-IgE- or substance P-induced histamine release from human lung. Theophylline caused a dose-related inhibition on these 3 models. We conclude that substance P is a modest secretagogue for human basophils and mast cells, and that skin and lung mast cells are heterogeneous with respect to their response to nedocromil sodium.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Louis, Renaud ;  Centre Hospitalier Universitaire de Liège - CHU > Pneumologie-Allergologie
Radermecker, Maurice ;  Centre Hospitalier Universitaire de Liège - CHU > Pneumologie-Allergologie
Language :
English
Title :
Substance P-induced histamine release from human basophils, skin and lung fragments: effect of nedocromil sodium and theophylline.
Publication date :
1990
Journal title :
International Archives of Allergy and Applied Immunology
ISSN :
0020-5915
Publisher :
Karger, Basel, Switzerland
Volume :
92
Issue :
4
Pages :
329-33
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 15 January 2010

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