Epithelial-to-mesenchymal transitions and circulating tumor cells.

[en] Epithelial-to-mesenchymal transition (EMT) phenomena endow epithelial cells with enhanced migratory and invasive potential, and as such, have been implicated in many physiological and pathological processes requiring cell migration/invasion. Although their involvement in the metastatic cascade is still a subject of debate, data are accumulating to demonstrate the existence of EMT phenotypes in primary human tumors, describe enhanced metastatic potential of EMT derivatives in animal models, and report EMT attributes in circulating tumor cells (CTCs). The relationships between EMT and CTCs remain largely unexplored, and we review here in vitro and in vivo data supporting a putative role of EMT processes in CTC generation and survival.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Bonnomet, A.

Brysse, Anne ; Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement

Tachsidis, A.

Waltham, M.

Thompson, E. W.

Polette, M.

Gilles, Christine ; Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement

Language :

English

Title :

Epithelial-to-mesenchymal transitions and circulating tumor cells.

Publication date :

2010

Journal title :

Journal of Mammary Gland Biology and Neoplasia

ISSN :

1083-3021

eISSN :

1573-7039

Publisher :

Kluwer Academic/Plenum Publishers, New York, United States - New York

Volume :

Issue :

Pages :

261-73

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 22 June 2010

Statistics

Number of views

171 (18 by ULiège)

Number of downloads

5 (2 by ULiège)

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Scopus citations^®

190

Scopus citations^®
without self-citations

178

OpenCitations

158

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