Article (Scientific journals)
Reduced intensity conditioning for allogeneic hematopoietic stem cell transplantation (HSCT)
Servais, Sophie; Beguin, Yves; Baron, Frédéric
2011In Belgian Journal of Hematology, 2, p. 3-9
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Keywords :
reduced-intensity conditioning; hematopoietic stem cell transplantation; graft-versus-tumor effects; graft-versus-host disease
Abstract :
[en] Reduced intensity conditioning (RIC) regimens have allowed performing allogeneic haematopoietic stem cell transplantation (HSCT) in patients for whom conventional myeloablative allogeneic HSCT is associated with unacceptable risks of non-relapse-mortality. This approac relies mainly on graft-versus-tumour effects for tumour eradication. Retrospective studies have suggested that, in patients aged 40 to 60 years, RIC-HSCT was associated with a higher risk of relapse but a lower incidence of transplant-related mortality than myeloablative allogeneic HSCT, leading to similar progression-free and overall survivals. After reviewing the rationale for RIC-HSCT, this article discusses the results of RIC-HSCT in specific deseases, and proposes what could be current indications for RIC-HSCT in 2011. Finally, the article briefly presents some possible strategies aimed at increasing the anti-tumoral activity of the procedure while reducing the incidence and severity of acute graft-versus-host disease.
Disciplines :
Hematology
Author, co-author :
Servais, Sophie ;  Université de Liège - ULiège > Frais communs médecine
Beguin, Yves  ;  Université de Liège - ULiège > GIGA-R : Hématologie
Baron, Frédéric  ;  Université de Liège - ULiège > GIGA-R : Hématologie - Département des sciences cliniques
Language :
English
Title :
Reduced intensity conditioning for allogeneic hematopoietic stem cell transplantation (HSCT)
Publication date :
2011
Journal title :
Belgian Journal of Hematology
ISSN :
2033-3749
Publisher :
Ariez Medical Publishing, Amsterdam, Netherlands
Volume :
2
Pages :
3-9
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 24 November 2010

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