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The role of dopaminergic signaling in the medial prefrontal cortex for the expression of cocaine-induced conditioned place preference in rats
https://doi.org/10.24517/00050520
https://doi.org/10.24517/00050520359b3dbd-6fda-4045-a4ca-9b04955377f1
名前 / ファイル | ライセンス | アクション |
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PH-PR-KANEDA-K-1983.pdf (1.4 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-04-16 | |||||
タイトル | ||||||
タイトル | The role of dopaminergic signaling in the medial prefrontal cortex for the expression of cocaine-induced conditioned place preference in rats | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00050520 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Shinohara, Fumiya
× Shinohara, Fumiya× Kamii, Hironori× Minami, Masabumi× Kaneda, Katsuyuki |
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著者別表示 |
金田, 勝幸
× 金田, 勝幸 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域薬学系 | |||||
書誌情報 |
Biological and Pharmaceutical Bulletin 巻 40, 号 11, p. 1983-1989, 発行日 2017 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0918-6158 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10885497 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/bpb.b17-00614 | |||||
出版者 | ||||||
出版者 | The Pharmaceutical Society of Japan = 日本薬学会 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The expression phase of cocaine-induced conditioned place preference (CPP) represents a cocaineseeking behavior triggered by contextual cues associated with the rewarding effects of cocaine. However, the exact mechanisms underlying the cocaine CPP expression remain unclear. Here, we investigated the role of dopaminergic (DAergic) transmission in the medial prefrontal cortex (mPFC) for the expression of cocaine CPP. An intra-ventral tegmental area (VTA) injection of a cocktail of γ-aminobutyric acid (GABA)B and GABAA receptor agonists (baclofen and muscimol, respectively) immediately before the posttest inhibited the expression of cocaine CPP. An intra-mPFC injection of a dopamine D1 but not D2 receptor antagonist before the posttest significantly attenuated CPP expression. Moreover, after the posttest, the number of cFos-positive mPFC neurons in rats that were conditioned with cocaine was significantly larger than that with saline. Additionally, photostimulation of channelrhodopsin-2 expressing fibers derived from the VTA induced cFos expression in the mPFC, and this induction was reduced by a prior systemic injection of a D1 receptor antagonist. These findings indicate that during the expression of cocaine CPP, enhanced DAergic transmission from the VTA to the mPFC stimulates D1 receptors; this results in the activation of mPFC neurons, further leading to the expression of cocaine CPP. © 2017 The Pharmaceutical Society of Japan. | |||||
権利 | ||||||
権利情報 | Copyright © The Pharmaceutical Society of Japan 日本薬学会 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.pharm.or.jp/ | |||||
関連名称 | http://www.pharm.or.jp/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.jstage.jst.go.jp/browse/bpb/-char/ja/ | |||||
関連名称 | https://www.jstage.jst.go.jp/browse/bpb/-char/ja/ |