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Methods and Results Using the Japanese Acute Coronary Syndrome Study database, 1,236 consecutive patients who were hospitalized within 48 h of onset of symptoms of AMI from January to December 2003 were evaluated. All-cause mortality, cardiac events and cardiovascular events were lower in patients treated with nitrates than in the untreated controls. However, these crude comparisons included several confounding factors on nitrate prescription. To minimize the effect of selection bias on outcomes, the technique of propensity score matching for clinical characteristics was used and distortion of effective nitrate treatment was excluded as much as possible. The results of propensity score matching showed that nitrate therapy had no impact on all-cause mortality, cardiac events and cardiovascular events at 30, 60 or 90 days, 6 months, 1 year, and 2 years follow-up. Conclusions Long-term nitrate therapy after AMI neither improves nor aggravates prognosis. 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Japanese Acute Coronary Syndrome Study (JACSS) Investigators.Long-term nitrate therapy after acute myocardial infarction does not improve or aggravate prognosis.
https://doi.org/10.24517/00014434
https://doi.org/10.24517/00014434b769af6a-a10d-40d4-94c5-d3b9a43cac6e
名前 / ファイル | ライセンス | アクション |
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ME-PR-YAMAGISHI-M-301.pdf (86.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-06-15 | |||||
タイトル | ||||||
タイトル | Japanese Acute Coronary Syndrome Study (JACSS) Investigators.Long-term nitrate therapy after acute myocardial infarction does not improve or aggravate prognosis. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00014434 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Kojima, Sunao
× Kojima, Sunao× Matsui, Kunihiko× Sakamoto, Tomohiro× Ishihara, Masaharu× Kimura, Kazuo× Miyazaki, Shunichi× Yamagishi, Masakazu× Tei, Chuwa× Hiraoka, Hisatoyo× Sonoda, Masahiro× Tsuchihashi, Kazufumi× Shimoyama, Nobuo× Honda, Takashi× Ogata, Yasuhiro× Ogawa, Hisao× The Japanese Acute Coronary Syndrome Study (JACSS) Investigators |
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著者別表示 |
山岸, 正和
× 山岸, 正和 |
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書誌情報 |
Circulation journal 巻 71, 号 3, p. 301-307, 発行日 2007-02-25 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1346-9843 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11591968 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1253/circj.71.301 | |||||
出版者 | ||||||
出版者 | Japanese Circulation Society = 日本循環器学会 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background There is conflicting information about whether nitrate treatment aggravates long-term prognosis, so the present retrospective study was designed to determine the effects of long-term nitrate therapy on major adverse events after acute myocardial infarction (AMI) in the coronary interventional era. Methods and Results Using the Japanese Acute Coronary Syndrome Study database, 1,236 consecutive patients who were hospitalized within 48 h of onset of symptoms of AMI from January to December 2003 were evaluated. All-cause mortality, cardiac events and cardiovascular events were lower in patients treated with nitrates than in the untreated controls. However, these crude comparisons included several confounding factors on nitrate prescription. To minimize the effect of selection bias on outcomes, the technique of propensity score matching for clinical characteristics was used and distortion of effective nitrate treatment was excluded as much as possible. The results of propensity score matching showed that nitrate therapy had no impact on all-cause mortality, cardiac events and cardiovascular events at 30, 60 or 90 days, 6 months, 1 year, and 2 years follow-up. Conclusions Long-term nitrate therapy after AMI neither improves nor aggravates prognosis. Prospective randomized clinical trials are warranted to determine the effects of long-term nitrate therapy for secondary prevention of AMI. (Circ J 2007; 71: 301 - 307) | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出版者照会後に全文公開 | |||||
権利 | ||||||
権利情報 | Copyright © 2007 THE JAPANESE CIRCULATION SOCIETY | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.jstage.jst.go.jp/browse/circj | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.j-circ.or.jp/english/ |