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Extent of preoperative false lumen thrombosis does not influence long-term survival in patients with acute type a aortic dissection

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posted on 2015-12-10, 11:25 authored by M. Larsen, K. Bartnes, T. T. Tsai, K. A. Eagle, A. Evangelista, C. A. Nienaber, Toru Suzuki, R. Fattori, J. B. Froehlich, S. Jutchison, T. M. Sundt, J. L. Januzzi, E. M. Isselbacher, D. G. Montgomery, T. Myrmel
Background: Partial thrombosis of the false lumen has been related to aortic growth, reoperations, and death in the chronic phase of type B and repaired type A aortic dissections. The impact of preoperative false lumen thrombosis has not been studied previously. We used data from a contemporary, multinational database on aortic dissections to evaluate whether different degrees of preoperative false lumen thrombosis influenced long‐term prognosis. Methods and Results: We examined the records of 522 patients with surgically treated acute type A aortic dissections who survived to discharge between 1996 and 2011. At the preoperative imaging, 414 (79.3%) patients had patent false lumens, 84 (16.1%) had partial thrombosis of the false lumen, and 24 (4.6%) had complete thrombosis of the false lumen. The annual median (interquartile range) aortic growth rates were 0.5 (−0.3 to 2.0) mm in the aortic arch, 2.0 (0.2 to 4.0) mm in the descending thoracic aorta, and similar regardless of the degree of false lumen thrombosis. The overall 5‐year survival rate was 84.7%, and it was not influenced by false lumen thrombosis (P=0.86 by the log‐rank test). Independent predictors of long‐term mortality were age >70 years (hazard ratio [HR], 2.34; 95% confidence interval [CI], 1.20 to 4.56, P=0.012) and postoperative cerebrovascular accident, coma, and/or renal failure (HR, 2.62; 95% CI, 1.40 to 4.92, P=0.003). Conclusions: Patients with acute type A aortic dissection who survive to discharge have a favorable prognosis. Preoperative false lumen thrombosis does not influence long‐term mortality, reintervention rates, or aortic growth.

History

Citation

Journal of the American Heart Association, 2013, 2 (4), p. e000112

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Cardiovascular Sciences

Version

  • VoR (Version of Record)

Published in

Journal of the American Heart Association

Publisher

American Heart Association

issn

2047-9980

Acceptance date

2013-07-01

Copyright date

2013

Available date

2015-12-10

Publisher version

http://jaha.ahajournals.org/content/2/4/e000112

Language

en

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