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miR-24 affects hair follicle morphogenesis targeting Tcf-3

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posted on 2016-01-06, 10:42 authored by I. Amelio, A. M. Lena, E. Bonanno, G. Melino, E. Candi
During embryonic development, hair follicles (HFs) develop from an epidermal–mesenchymal cross talk between the ectoderm progenitor layer and the underlying dermis. Epidermal stem cell activation represents a crucial point both for HF morphogenesis and for hair regeneration. miR-24 is an anti-proliferative microRNA (miRNA), which is induced during differentiation of several cellular systems including the epidermis. Here, we show that miR-24 is expressed in the HF and has a role in hair morphogenesis. We generated transgenic mice ectopically expressing miR-24 under the K5 promoter. The K5::miR-24 animals display a marked defect in HF morphogenesis, with thinning of hair coat and altered HF structure. Expression of miR-24 alters the normal process of hair keratinocyte differentiation, leading to altered expression of differentiation markers. MiR-24 directly represses the hair keratinocyte stemness regulator Tcf-3. These results support the notion that microRNAs, and among them miR-24, have an important role in postnatal epidermal homeostasis.

History

Citation

Cell Death and Disease (2013) 4, e922

Version

  • VoR (Version of Record)

Published in

Cell Death and Disease (2013) 4

Publisher

Nature Publishing Group for Associazione Differenziamento e Morte Cellulare

issn

2041-4889

eissn

2041-4889

Acceptance date

2013-09-30

Available date

2016-01-06

Publisher version

http://www.nature.com/cddis/journal/v4/n11/full/cddis2013426a.html

Language

en

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