Open Collections

UBC Faculty Research and Publications

Bioactive Agent-Loaded Electrospun Nanofiber Membranes for Accelerating Healing Process: A Review Mousavi, Seyyed-Mojtaba; Nejad, Zohre Mousavi; Hashemi, Seyyed Alireza; Salari, Marjan; Gholami, Ahmad; Ramakrishna, Seeram; Chiang, Wei-Hung; Lai, Chin Wei

Abstract

Despite the advances that have been achieved in developing wound dressings to date, wound healing still remains a challenge in the healthcare system. None of the wound dressings currently used clinically can mimic all the properties of normal and healthy skin. Electrospinning has gained remarkable attention in wound healing applications because of its excellent ability to form nanostructures similar to natural extracellular matrix (ECM). Electrospun dressing accelerates the wound healing process by transferring drugs or active agents to the wound site sooner. This review provides a concise overview of the recent developments in bioactive electrospun dressings, which are effective in treating acute and chronic wounds and can successfully heal the wound. We also discuss bioactive agents used to incorporate electrospun wound dressings to improve their therapeutic potential in wound healing. In addition, here we present commercial dressings loaded with bioactive agents with a comparison between their features and capabilities. Furthermore, we discuss challenges and promises and offer suggestions for future research on bioactive agent-loaded nanofiber membranes to guide future researchers in designing more effective dressing for wound healing and skin regeneration.

Item Metadata

Title
Bioactive Agent-Loaded Electrospun Nanofiber Membranes for Accelerating Healing Process: A Review
Creator
Mousavi, Seyyed-Mojtaba; Nejad, Zohre Mousavi; Hashemi, Seyyed Alireza; Salari, Marjan; Gholami, Ahmad; Ramakrishna, Seeram; Chiang, Wei-Hung; Lai, Chin Wei
Contributor
University of British Columbia. Nanomaterials and Polymer Nanocomposites Laboratory
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2021-09-13
Description
Despite the advances that have been achieved in developing wound dressings to date, wound healing still remains a challenge in the healthcare system. None of the wound dressings currently used clinically can mimic all the properties of normal and healthy skin. Electrospinning has gained remarkable attention in wound healing applications because of its excellent ability to form nanostructures similar to natural extracellular matrix (ECM). Electrospun dressing accelerates the wound healing process by transferring drugs or active agents to the wound site sooner. This review provides a concise overview of the recent developments in bioactive electrospun dressings, which are effective in treating acute and chronic wounds and can successfully heal the wound. We also discuss bioactive agents used to incorporate electrospun wound dressings to improve their therapeutic potential in wound healing. In addition, here we present commercial dressings loaded with bioactive agents with a comparison between their features and capabilities. Furthermore, we discuss challenges and promises and offer suggestions for future research on bioactive agent-loaded nanofiber membranes to guide future researchers in designing more effective dressing for wound healing and skin regeneration.
Subject
wound dressing; bioactive molecules; wound healing; electrospinning; tissue engineering
Genre
Article
Type
Text
Language
eng
Date Available
2021-10-13
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0402514
URI
http://hdl.handle.net/2429/79958
Affiliation
Applied Science, Faculty of; Non UBC; Engineering, School of (Okanagan)
Citation
Membranes 11 (9): 702 (2021)
Publisher DOI
10.3390/membranes11090702
Peer Review Status
Reviewed
Scholarly Level
Faculty
Rights URI
https://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

Item Media

Item Citations and Data

Rights

CC BY 4.0