尿中申性17-KetosteroidsのPolarograph的定量の研究 第III篇:精神薄弱少年の尿中中性17-KetosteroidsのPolarograph的測定による研究

Abstract

Polarographic quantitative analysis of urinary 17-ketos t e roids has been described in Part I and II. Analysis of urinary 17-ketosteroids of the neurasthenics at the Kyoto Medical Juvenile Reformatory were undertaken. Few reports are available at p r e sent regarding to urinary 17-ketosteroids of the neurasthenics. Daily output of 17-ketosteroids, chromatographic pattern, diurnal variation and ACTH-test were carried out in 65 subjects consisted of 35 neurasthenics at the reformatory whose ages ranged between 17 and 22 years , 15 normal males of the same range of age at the reformatory and 15 normal males in the community. 1) The average urinary output of 17-ketosteroids in the neurasthenics was 7.85 mg/day (4.87-12.6m g/day), which was lower than that (8.45m g/day) of normal males at the reformatory and that (9.04 mg/day) of normal males in the community. 2) In chromatographic pattern of 17-ketosteroids, IV+V was low e r in the neurasthenics than in the rest of 2 groups. But the ratio of IV-MTto VI+VII was mor e than 1.75 and IV was higher than V. 3) There was no s ignif i i cant d fference in diurnal variation between the normal males in the reformatory and the community. The standard deviation of fracti on was within 4.2 per cent. 4) I n ACTH-test, fraction of VI, VII and III was remarkably increased, while IV, V was not changed significantly. 5) Each polar o gram of fraction III, IV, VI+VII produced by 17-ketosteroids extracted from the urine collected during the period of before and after 24 hours of ACTH-test.