膀胱腫瘍に対するCarboquone膀胱腔内注入療法の基礎的,臨床的検討

Abstract

Carboquone preparations, Esquinone for injection and Esquinone injection, were infused into the bladder to investigate their antitumor activity and inactivation of carboquone in urine in 72 patients with superficial bladder tumors. The following conclusions were obtained: 1. Stability of carboquone was highly dependent on pH of the urine mixed with it. Its inactivation was marked at acidic pH. Reduction of the amount of urine during infusion and use of a larger amount of diluent are important to prevent the inactivation of carboquone. 2. Intra-vesical infusion of carboquone was evaluated to be effective in 51.4% patients. 3. No special difference in effectiveness was found between Esquinone for injection and Esquinone injection. 4. No difference in effectiveness was found between the patients with primary tumors and those with recurrent tumors. 5. As for side effects, Esquinone for injection and Esquinone injection caused irritant symptoms of the bladder in 36.4 and 52.0% of patients, respectively. 6. Carboquinone infused into the bladder had no influence on peripheral blood, liver function, and renal function.