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タイトル: | The effect of β-2 adrenoreceptor agonist inhalation on lungs donated after cardiac death in a canine lung transplantation model. |
著者: | Sakamoto, Jin Chen, Fengshi Nakajima, Daisuke Yamada, Tetsu Ohsumi, Akihiro Zhao, Xiangdong https://orcid.org/0000-0002-0714-5064 (unconfirmed) Sakai, Hiroaki Bando, Toru Date, Hiroshi |
著者名の別形: | 阪本, 仁 伊達, 洋至 |
キーワード: | β-2 adrenoreceptor agonist canine model donation after cardiac death inhalation lung transplantation |
発行日: | Jul-2012 |
出版者: | Elsevier Inc. |
誌名: | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation |
巻: | 31 |
号: | 7 |
開始ページ: | 773 |
終了ページ: | 779 |
抄録: | [Background]It is a matter of great importance in a donation after cardiac death to attenuate ischemia–reperfusion injury (IRI) related to the inevitable warm ischemic time. [Methods]Donor dogs were rendered cardiac-dead and left at room temperature. The dogs were allocated into 2 groups: the β-2 group (n = 5) received an aerosolized β-2 adrenoreceptor agonist (procaterol, 350 μg) and ventilation with 100% oxygen for 60 minutes starting at 240 minutes after cardiac arrest, and the control group (n = 6) received an aerosolized control solvent with the ventilation. Lungs were recovered 300 minutes after cardiac arrest. Recipient dogs underwent left single-lung transplantation to evaluate the functions of the left transplanted lung for 240 minutes after the reperfusion. [Results]Oxygenation and dynamic compliance were significantly higher in the β-2 group than in the control group. The β-2 group revealed significantly higher levels of cyclic adenosine monophosphate and high-energy phosphates in the donor lung after the inhalation than before it. Histologic findings revealed that the β-2 group had less edema and fewer inflammatory cells. [Conclusion]Our results suggest that β-2 adrenoreceptor agonist inhalation during the pre-procurement period may ameliorate IRI. |
著作権等: | © 2012 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/158356 |
DOI(出版社版): | 10.1016/j.healun.2012.03.012 |
PubMed ID: | 22534458 |
出現コレクション: | 学術雑誌掲載論文等 |
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