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タイトル: | Sputum YKL-40 Levels and Pathophysiology of Asthma and Chronic Obstructive Pulmonary Disease. |
著者: | Otsuka, Kojiro Matsumoto, Hisako Niimi, Akio Muro, Shigeo Ito, Isao https://orcid.org/0000-0003-3109-898X (unconfirmed) Takeda, Tomoshi Terada, Kunihiko Yamaguchi, Masafumi Matsuoka, Hirofumi Jinnai, Makiko Oguma, Tsuyoshi Nakaji, Hitoshi Inoue, Hideki Tajiri, Tomoko Iwata, Toshiyuki Chin, Kazuo Mishima, Michiaki |
著者名の別形: | 松本, 久子 |
発行日: | 2012 |
出版者: | Karger |
誌名: | Respiration; international review of thoracic diseases |
巻: | 83 |
号: | 6 |
開始ページ: | 507 |
終了ページ: | 519 |
抄録: | Background: Recent evidence suggests that YKL-40, also called chitinase-3-like-1 protein, is involved in the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD). Details of sputum YKL-40 in asthma and COPD, however, remain unknown. Objectives: To clarify associations of sputum YKL-40 levels with clinical indices in asthma and COPD. Methods: Thirty-nine patients with asthma, 14 age-matched never-smokers as controls, 45 patients with COPD, and 7 age-matched smokers as controls were recuited for this study. Sputum YKL-40 levels were measured and YKL-40 expression in sputum cells was evaluated by immunocytochemistry. Results: Sputum YKL-40 levels were higher in patients with COPD (346 ± 325 ng/ml) than in their smoker controls (125 ± 122 ng/ml; p < 0.05), but were not significantly different between patients with asthma (117 ± 170 ng/ml) and their controls (94 ± 44 ng/ml; p = 0.15). In patients with asthma only, sputum YKL-40 levels were positively correlated with disease severity (r = 0.34, p = 0.034) and negatively correlated with pre- and postbronchodilator %FEV(1) (r = -0.47 and -0.42, respectively; p < 0.01) and forced mid-expiratory flow (r = -0.48 and -0.46, respectively, p < 0.01). Sputum YKL-40 levels were positively correlated with sputum neutrophil counts in asthma (r = 0.55, p < 0.001) and with neutrophil and macrophage counts in COPD (r = 0.45 and 0.65, respectively, p < 0.01). YKL-40 was expressed in the cytoplasm of sputum neutrophils and macrophages in all groups. Conclusions: Elevated sputum YKL-40 reflects airflow obstruction in asthma whereas the roles of YKL-40 in the proximal airways in COPD remain to be elucidated. |
著作権等: | © 2011 S. Karger AG, Basel This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/158368 |
DOI(出版社版): | 10.1159/000330840 |
PubMed ID: | 21968467 |
出現コレクション: | 学術雑誌掲載論文等 |
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