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ファイル | 記述 | サイズ | フォーマット | |
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j.biomaterials.2011.04.035.pdf | 1.38 MB | Adobe PDF | 見る/開く |
タイトル: | Enhancement of ectopic osteoid formation following the dual release of bone morphogenetic protein 2 and Wnt1 inducible signaling pathway protein 1 from gelatin sponges. |
著者: | Kohara, Hiroshi Tabata, Yasuhiko |
著者名の別形: | 田畑, 泰彦 |
キーワード: | Controlled release BMP2 WISP1 Bone formation Age-related change |
発行日: | Aug-2011 |
出版者: | Elsevier Ltd. |
誌名: | Biomaterials |
巻: | 32 |
号: | 24 |
開始ページ: | 5726 |
終了ページ: | 5732 |
抄録: | Bone morphogenetic protein (BMP) 2-incorporated gelatin sponge is effective for in vivo osteoinduction. However, the modeling capacity of bone decreases with age. As atrial to stimulate effective bone formation for animals with decreased osteogenic potential, Wnt1 inducible signaling pathway protein (WISP) 1, an osteoblastic regulator, was combined with gelatin sponge incorporating BMP2. Osteopontin (Opn) geneexpression was increased in vitro for mouse bone marrow stromal cells (BMSC) cultured in gelatin sponges incorporating BMP2 and WISP1 compared with those incorporating BMP2 or WISP1 alone. In vivo synergistic effect of BMP2 and WISP1 on the ectopic osteoid formation was observed when gelatin sponges incorporating BMP2 and WISP1 were implanted subcutaneously into middle-aged mice with decreased bone formation potential. It is concluded that the scaffold incorporating multiple osteoinductive agents could be effective in inducing bone formation in those with age-related decreased potential of bone formation. |
著作権等: | © 2011 Elsevier Ltd. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/159455 |
DOI(出版社版): | 10.1016/j.biomaterials.2011.04.035 |
PubMed ID: | 21570720 |
出現コレクション: | 学術雑誌掲載論文等 |
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