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タイトル: | Chemokine-dependent T cell migration requires aquaporin-3-mediated hydrogen peroxide uptake. |
著者: | Hara-Chikuma, Mariko Chikuma, Shunsuke Sugiyama, Yoshinori Kabashima, Kenji https://orcid.org/0000-0002-0773-0554 (unconfirmed) Verkman, Alan S Inoue, Shintaro Miyachi, Yoshiki |
著者名の別形: | 竹馬, 真理子 |
発行日: | 24-Sep-2012 |
出版者: | The Rockefeller University Press |
誌名: | The Journal of experimental medicine |
巻: | 209 |
号: | 10 |
開始ページ: | 1743 |
終了ページ: | 1752 |
抄録: | Chemokine-dependent trafficking is indispensable for the effector function of antigen-experienced T cells during immune responses. In this study, we report that the water/glycerol channel aquaporin-3 (AQP3) is expressed on T cells and regulates their trafficking in cutaneous immune reactions. T cell migration toward chemokines is dependent on AQP3-mediated hydrogen peroxide (H(2)O(2)) uptake but not the canonical water/glycerol transport. AQP3-mediated H(2)O(2) transport is essential for the activation of the Rho family GTPase Cdc42 and the subsequent actin dynamics. Coincidentally, AQP3-deficient mice are defective in the development of hapten-induced contact hypersensitivity, which is attributed to the impaired trafficking of antigen-primed T cells to the hapten-challenged skin. We therefore suggest that AQP3-mediated H(2)O(2) uptake is required for chemokine-dependent T cell migration in sufficient immune response. |
著作権等: | c 2012 Hara-Chikuma et al. This article is distributed under the terms of an Attribution?Noncommercial?Share Alike?No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution?Noncommercial? Share Alike 3.0 Unported license, as described at http://creativecommons.org/ licenses/by-nc-sa/3.0/). |
URI: | http://hdl.handle.net/2433/166329 |
DOI(出版社版): | 10.1084/jem.20112398 |
PubMed ID: | 22927550 |
出現コレクション: | 学術雑誌掲載論文等 |
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