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j.jconrel.2013.10.039.pdf | 1.82 MB | Adobe PDF | 見る/開く |
タイトル: | Photothermal ablation of tumor cells using a single-walled carbon nanotube-peptide composite. |
著者: | Hashida, Yasuhiko Tanaka, Hironori Zhou, Shuwen Kawakami, Shigeru Yamashita, Fumiyoshi https://orcid.org/0000-0002-3503-8696 (unconfirmed) Murakami, Tatsuya Umeyama, Tomokazu https://orcid.org/0000-0003-4145-5784 (unconfirmed) Imahori, Hiroshi Hashida, Mitsuru |
著者名の別形: | 橋田, 泰彦 川上, 茂 橋田, 充 |
キーワード: | Single-walled carbon nanotube Single-walled carbon nanotube–peptide composite Near-infrared laser irradiation Tumor ablation Photothermal cancer therapy Aqueous dispersibility |
発行日: | 10-Jan-2014 |
出版者: | Elsevier BV |
誌名: | Journal of controlled release |
巻: | 173 |
開始ページ: | 59 |
終了ページ: | 66 |
抄録: | Single-walled carbon nanotubes (SWCNTs) are known to have great potential for biomedical applications such as photothermal ablation of tumor cells in combination with near-infrared (NIR) irradiation. In this study, the photothermal activity of a novel SWCNTs composite with a designed peptide having a repeated structure of H-(-Lys-Phe-Lys-Ala-)7-OH [(KFKA)7] against tumor cells was evaluated in vitro and in vivo. The SWCNT-(KFKA)7 composite demonstrated high aqueous dispersibility that enabled SWCNTs to be used in tumor ablation. The NIR irradiation of SWCNT-(KFKA)7 solution resulted in a rapid temperature increase dependent on the SWCNTs concentration up to 50μg/ml. Three minutes of NIR irradiation of a colon 26 or HepG2 cell culture incubated with SWCNT-(KFKA)7 resulted in remarkable cell damage, while that by single treatment with SWCNT-(KFKA)7 or NIR irradiation alone was moderate. The intratumoral injection of SWCNT-(KFKA)7 solution followed by NIR irradiation resulted in a rapid increase of the temperature to 43°C in the subcutaneously inoculated colon 26 tumor based on thermographic observation and remarkable suppression of tumor growth compared with treatment with only SWCNT-(KFKA)7 injection alone or NIR irradiation alone. These results suggest the a great potential of an SWCNT-peptide composite for use in photothermal cancer therapy. |
著作権等: | © 2013 Elsevier B.V. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/189759 |
DOI(出版社版): | 10.1016/j.jconrel.2013.10.039 |
PubMed ID: | 24211651 |
出現コレクション: | 学術雑誌掲載論文等 |
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