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タイトル: | Controversies over the Epithelial-to-Mesenchymal Transition in Liver Fibrosis |
著者: | Taura, Kojiro Iwaisako, Keiko Hatano, Etsuro Uemoto, Shinji |
著者名の別形: | 田浦, 康二朗 祝迫, 惠子 波多野, 悦朗 上本, 伸二 |
キーワード: | epithelial-to-mesenchymal transition (EMT) liver fibrosis myofibroblast hepatocyte cholangiocyte |
発行日: | 14-Jan-2016 |
出版者: | MDPI AG |
誌名: | Journal of clinical medicine |
巻: | 5 |
号: | 1 |
論文番号: | 9 |
抄録: | Liver fibrosis is a universal consequence of chronic liver diseases. It is accompanied by activation of collagen-producing myofibroblasts, resulting in excessive deposition of extracellular matrix. The origin of myofibroblasts in the fibrotic liver has not been completely resolved and remains a matter of debate. Recently, the epithelial-to-mesenchymal transition (EMT) was proposed as one of the mechanisms that give rise to collagen-producing myofibroblasts in liver fibrosis. However, subsequent studies contradicted this hypothesis, and the EMT theory has become one of the most controversial and debatable issues in the field of liver fibrosis research. This review will summarize the existing literature on EMT in liver fibrosis and will analyze the causes for the contradictory results to draw a reasonable conclusion based on current knowledge in the field. |
著作権等: | This is an open access article distributed under the Creative Commons Attribution License (CC BY 4.0). |
URI: | http://hdl.handle.net/2433/216279 |
DOI(出版社版): | 10.3390/jcm5010009 |
PubMed ID: | 26784242 |
出現コレクション: | 学術雑誌掲載論文等 |
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