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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| ange.201411954.pdf | 568.17 kB | Adobe PDF | 見る/開く |
| タイトル: | Total Synthesis of (−)-Caprazamycin A |
| 著者: | Nakamura, Hugh Tsukano, Chihiro    https://orcid.org/0000-0002-9361-0857 (unconfirmed)Yasui, Motohiro Yokouchi, Shinsuke Igarashi, Masayuki Takemoto, Yoshiji |
| 著者名の別形: | 中村, 斐有 塚野, 千尋 安井, 基博 竹本, 佳司 |
| キーワード: | Aldolreaktionen Antibiotika Naturstoffe Organokatalyse Totalsynthesen |
| 発行日: | 2-Mar-2015 |
| 出版者: | Wiley |
| 誌名: | Angewandte Chemie |
| 巻: | 127 |
| 号: | 10 |
| 開始ページ: | 3179 |
| 終了ページ: | 3182 |
| 抄録: | Caprazamycin A has significant antibacterial activity against Mycobacterium tuberculosis (TB). The first total synthesis is herein reported and features a) the scalable preparation of the syn‐β‐hydroxy amino acid with a thiourea‐catalyzed diastereoselective aldol reaction, b) construction of a diazepanone with an unstable fatty‐acid side chain, and c) global deprotection with hydrogenation. This report provides a route for the synthesis of related liponucleoside antibiotics with fatty‐acid side chains. |
| 著作権等: | This is the peer reviewed version of the following article: Hugh Nakamura, Chihiro Tsukano, Motohiro Yasui, Shinsuke Yokouchi, Masayuki Igarashi, Yoshiji Takemoto, Total Synthesis of (−)-Caprazamycin A, Angewandte Chemie, 127, 10, (3179-3182), (2015) which has been published in final form at https://doi.org/10.1002/ange.201411954. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
| URI: | http://hdl.handle.net/2433/235941 |
| DOI(出版社版): | 10.1002/ange.201411954 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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