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タイトル: | A Descending Circuit Derived From the Superior Colliculus Modulates Vibrissal Movements |
著者: | Kaneshige, Miki Shibata, Ken-ichi Matsubayashi, Jun Mitani, Akira Furuta, Takahiro |
著者名の別形: | 兼重, 美希 松林, 潤 三谷, 章 古田, 貴寛 |
キーワード: | whisker premotor neurons rat anterograde tracing kinematic analysis CPGs |
発行日: | 22-Nov-2018 |
出版者: | Frontiers Media SA |
誌名: | Frontiers in Neural Circuits |
巻: | 12 |
論文番号: | 100 |
抄録: | The superior colliculus (SC) is an essential structure for the control of eye movements. In rodents, the SC is also considered to play an important role in whisking behavior, in which animals actively move their vibrissae (mechanosensors) to gather tactile information about the space around them during exploration. We investigated how the SC contributes to vibrissal movement control. We found that when the SC was unilaterally lesioned, the resting position of the vibrissae shifted backward on the side contralateral to the lesion. The unilateral SC lesion also induced an increase in the whisking amplitude on the contralateral side. To explore the anatomical basis for SC involvement in vibrissal movement control, we then quantitatively evaluated axonal projections from the SC to the brainstem using neuronal labeling with a virus vector. Neurons of the SC mainly sent axons to the contralateral side in the lower brainstem. We found that the facial nucleus received input directly from the SC, and that the descending projections from the SC also reached the intermediate reticular formation and pre-Bötzinger complex, which are both considered to contain neural oscillators generating rhythmic movements of the vibrissae. Together, these results indicate the existence of a neural circuit in which the SC modulates vibrissal movements mainly on the contralateral side, via direct connections to motoneurons, and via indirect connections including the central pattern generators. |
著作権等: | © 2018 Kaneshige, Shibata, Matsubayashi, Mitani and Furuta. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
URI: | http://hdl.handle.net/2433/241761 |
DOI(出版社版): | 10.3389/fncir.2018.00100 |
PubMed ID: | 30524249 |
出現コレクション: | 学術雑誌掲載論文等 |
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