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タイトル: | Divergent Dynamics and Functions of ERK MAP Kinase Signaling in Development, Homeostasis and Cancer: Lessons from Fluorescent Bioimaging |
著者: | Muta, Yu Matsuda, Michiyuki https://orcid.org/0000-0002-5876-9969 (unconfirmed) Imajo, Masamichi |
著者名の別形: | 牟田, 優 松田, 道行 今城, 正道 |
キーワード: | ERK MAP kinase molecular activity dynamics bioimaging cancer |
発行日: | 10-Apr-2019 |
出版者: | MDPI AG |
誌名: | Cancers |
巻: | 11 |
号: | 4 |
論文番号: | 513 |
抄録: | The extracellular signal-regulated kinase (ERK) signaling pathway regulates a variety of biological processes including cell proliferation, survival, and differentiation. Since ERK activation promotes proliferation of many types of cells, its deregulated/constitutive activation is among general mechanisms for cancer. Recent advances in bioimaging techniques have enabled to visualize ERK activity in real-time at the single-cell level. Emerging evidence from such approaches suggests unexpectedly complex spatiotemporal dynamics of ERK activity in living cells and animals and their crucial roles in determining cellular responses. In this review, we discuss how ERK activity dynamics are regulated and how they affect biological processes including cell fate decisions, cell migration, embryonic development, tissue homeostasis, and tumorigenesis. |
著作権等: | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
URI: | http://hdl.handle.net/2433/254110 |
DOI(出版社版): | 10.3390/cancers11040513 |
PubMed ID: | 30974867 |
出現コレクション: | 学術雑誌掲載論文等 |
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