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タイトル: | Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion |
著者: | Kawai, Hiroyuki Bouchekioua, Youcef Nishitani, Naoya Niitani, Kazuhei Izumi, Shoma Morishita, Hinako Andoh, Chihiro Nagai, Yuma Koda, Masashi Hagiwara, Masako Toda, Koji Shirakawa, Hisashi ![]() ![]() ![]() Nagayasu, Kazuki Ohmura, Yu Kondo, Makoto Kaneda, Katsuyuki Yoshioka, Mitsuhiro Kaneko, Shuji ![]() ![]() ![]() |
著者名の別形: | 河合, 洋幸 ブシェキワ, ユセフ 西谷, 直也 二井谷, 和平 泉, 翔馬 森下, 雛子 安藤, 千紘 永井, 佑茉 好田, 匡志 萩原, 雅子 兎田, 幸司 白川, 久志 永安, 一樹 大村, 優 近藤, 誠 金田, 勝幸 吉岡, 充弘 金子, 周司 |
キーワード: | Neuroscience Reward |
発行日: | 2022 |
出版者: | Springer Nature |
誌名: | Nature Communications |
巻: | 13 |
論文番号: | 7708 |
抄録: | Appropriate processing of reward and aversive information is essential for survival. Although a critical role of serotonergic neurons in the dorsal raphe nucleus (DRN) in reward processing has been shown, the lack of rewarding effects with selective serotonin reuptake inhibitors (SSRIs) implies the presence of a discrete serotonergic system playing an opposite role to the DRN in the processing of reward and aversive stimuli. Here, we demonstrated that serotonergic neurons in the median raphe nucleus (MRN) of mice process reward and aversive information in opposite directions to DRN serotonergic neurons. We further identified MRN serotonergic neurons, including those projecting to the interpeduncular nucleus (5-HTMRN→IPN), as a key mediator of reward and aversive stimuli. Moreover, 5-HT receptors, including 5-HT2A receptors in the interpeduncular nucleus, are involved in the aversive properties of MRN serotonergic neural activity. Our findings revealed an essential function of MRN serotonergic neurons, including 5-HTMRN→IPN, in the processing of reward and aversive stimuli. |
記述: | 不快感を誘発するセロトニン神経を発見 --セロトニン神経の多様性が明らかに--. 京都大学プレスリリース. 2022-12-23. |
著作権等: | © The Author(s) 2022 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. |
URI: | http://hdl.handle.net/2433/278124 |
DOI(出版社版): | 10.1038/s41467-022-35346-7 |
PubMed ID: | 36550097 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2022-12-23-0 |
出現コレクション: | 学術雑誌掲載論文等 |
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