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j.bbmt.2009.04.008.pdf | 720.64 kB | Adobe PDF | 見る/開く |
タイトル: | Clinical Significance of Serum Hepcidin Levels on Early Infectious Complications in Allogeneic Hematopoietic Stem Cell Transplantation |
著者: | Kanda, Junya https://orcid.org/0000-0002-6704-3633 (unconfirmed) Mizumoto, Chisaki Kawabata, Hiroshi Ichinohe, Tatsuo Tsuchida, Hideyuki Tomosugi, Naohisa Matsuo, Keitaro Yamashita, Kouhei Kondo, Tadakazu https://orcid.org/0000-0002-8959-6271 (unconfirmed) Ishikawa, Takayuki Uchiyama, Takashi |
著者名の別形: | 諫田, 淳也 |
キーワード: | Allogeneic stem cell transplantation Bacterial infection Hepcidin |
発行日: | Aug-2009 |
出版者: | Elsevier |
誌名: | Biology of Blood and Marrow Transplantation |
巻: | 15 |
号: | 8 |
開始ページ: | 956 |
終了ページ: | 962 |
抄録: | The association of iron overload with complications of allogeneic hematopoietic stem cell transplantation (HSCT) has been suggested in previous studies. Because hepcidin plays a central role in the regulation of iron homeostasis, we analyzed the association between pretransplant serum hepcidin-25 levels and early infectious complications after allogeneic HSCT. We studied 55 consecutive adult patients with a median age of 47 years (range: 20-64 years) who underwent allogeneic HSCT for hematologic malignancies at our institution. Thirty-two patients had myelogenous malignancies; the remaining 23 had lymphogenous malignancies. The median pretransplant serum hepcidin level of patients in the study was 21.6 ng/mL (range: 1.4-371 ng/mL), which was comparable to that of healthy volunteers (median: 19.1 ng/mL [range: 2.3-37 ng/mL]; n = 17). When cumulative incidences of documented bacterial and cytomegalovirus (CMV) infections at day 100 were compared according to pretransplant hepcidin-25 levels, the incidence of bacterial, but not CMV, infection, was significantly higher in the high-hepcidin group (?50 ng/mL; n = 17) than in the low-hepcidin group (<50 ng/mL; n = 38) (65% [95% confidence interval, 38%-82%] versus 11% [3%-23%]; P < .001). This finding was confirmed by multivariate Cox analysis adjusted for confounders, including pretransplant ferritin and C-reactive protein (CRP) levels. No fungal infection was documented in either group. These results suggest that the pretransplant serum hepcidin-25 level may be a useful marker for predicting the risk of early bacterial complications after allogeneic HSCT. Larger prospective studies are, however, warranted to confirm our findings. |
著作権等: | c 2009 American Society for Blood and Marrow Transplantation. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/84530 |
DOI(出版社版): | 10.1016/j.bbmt.2009.04.008 |
PubMed ID: | 19589485 |
関連リンク: | http://www.scopus.com/inward/record.url?eid=2-s2.0-67649619559&partnerID=40 |
出現コレクション: | 学術雑誌掲載論文等 |
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