Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/106163
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Distinct sex-specific gene expression changes in the placenta in association with childhood allergy |
Author: | Tuck, A. Grzeskowiak, L. Osei-Kumah, A. Saif, Z. Edwards, S. Tai, A. Prescott, S. Tulic, M. Saffery, R. Clifton, V. |
Citation: | International Journal of Respiratory and Pulmonary Medicine, 2015; 2(4):1-7 |
Publisher: | ClinMed International Library |
Issue Date: | 2015 |
ISSN: | 2378-3516 |
Statement of Responsibility: | Astrud R Tuck, Luke E Grzeskowiak, Annette Osei-Kumah, Zarqa Saif, Suzanne M Edwards, Andrew Tai, Susan L Prescott, MeriTulic, Richard Saffery, and Vicki L Clifton |
Abstract: | BACKGROUND: The prevalence of allergic disease has risen significantly during recent years. A major component of the susceptibility to allergic disease is determined in prenatal life, when the placenta plays a central role in fetal growth and development. In this study, we aimed to identify the patterns of gene expression in the placenta that may program early immune function to increase susceptibility to allergy. METHODS: A set of immune genes known to be associated with asthma, allergy and inflammation were selected for analysis by quantitative real-time polymerase chain reaction (qRT-PCR) on placental tissue from infants who did or did not develop an allergy by 2 years of age. Analysis was performed on males and females separately for each allergy type including eczema, rhinitis or asthma. RESULTS: Of 11 candidate allergy-associated genes tested by qRT-PCR, 4 were found to be associated with the development of specific childhood allergy types (P < 0.05). These included MMP9 for both males and females that developed eczema, TLR7 for females that developed eczema, KITL1 for males that developed rhinitis and ORMDL3 for females that developed asthma. CONCLUSIONS: This study has identified altered expression of placental genes involved in inflammation in association with the development of specific allergies in childhood. The current data provide supporting evidence implicating the placenta in programming the fetal immune system in early life. |
Keywords: | Human; Placenta; Allergy; Child; Gene; Immune; Eczema; Rhinitis; Asthma |
Rights: | © 2015 Tuck AR. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
DOI: | 10.23937/2378-3516/1410033 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1002381 http://purl.org/au-research/grants/nhmrc/1041918 |
Published version: | http://dx.doi.org/10.23937/2378-3516/1410033 |
Appears in Collections: | Aurora harvest 8 Paediatrics publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
hdl_106163.pdf | Published version | 833.21 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.