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https://hdl.handle.net/2440/106762
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Type: | Journal article |
Title: | In depth analysis of the Sox4 gene locus that consists of sense and natural antisense transcripts |
Author: | Ling, K. Brautigan, P. Moore, S. Fraser, R. Leong, M. Leong, J. Zainal Abidin, S. Lee, H. Cheah, P. Raison, J. Babic, M. Lee, Y. Daish, T. Mattiske, D. Mann, J. Adelson, D. Thomas, P. Hahn, C. Scott, H. |
Citation: | Data in Brief, 2016; 7:282-290 |
Publisher: | Elsevier |
Issue Date: | 2016 |
ISSN: | 2352-3409 2352-3409 |
Statement of Responsibility: | King-Hwa Ling, Peter J. Brautigan, Sarah Moore, Rachel Fraser, Melody Pui-Yee Leong, Jia-Wen Leong, Shahidee Zainal Abidin, Han-Chung Lee, Pike-See Cheah, Joy M. Raison, Milena Babic, Young Kyung Lee, Tasman Daish, Deidre M. Mattiske, Jeffrey R. Mann, David L. Adelson, Paul Q. Thomas, Christopher N. Hahn, Hamish S.Scott |
Abstract: | SRY (Sex Determining Region Y)-Box 4 or Sox4 is an important regulator of the pan-neuronal gene expression during post-mitotic cell differentiation within the mammalian brain. Sox4 gene locus has been previously characterized with multiple sense and overlapping natural antisense transcripts [1], [2]. Here we provide accompanying data on various analyses performed and described in Ling et al. [2]. The data include a detail description of various features found at Sox4 gene locus, additional experimental data derived from RNA-Fluorescence in situ Hybridization (RNA-FISH), Western blotting, strand-specific reverse-transcription quantitative polymerase chain reaction (RT-qPCR), gain-of-function and in situ hybridization (ISH) experiments. All the additional data provided here support the existence of an endogenous small interfering- or PIWI interacting-like small RNA known as Sox4_sir3, which origin was found within the overlapping region consisting of a sense and a natural antisense transcript known as Sox4ot1. |
Keywords: | Endogenous siRNA Brain development Natural antisense transcripts |
Description: | Available online 17 February 2016 |
Rights: | © 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
DOI: | 10.1016/j.dib.2016.01.045 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/171601 http://purl.org/au-research/grants/nhmrc/461204 http://purl.org/au-research/grants/nhmrc/219176 http://purl.org/au-research/grants/nhmrc/257501 http://purl.org/au-research/grants/nhmrc/257529 |
Published version: | http://dx.doi.org/10.1016/j.dib.2016.01.045 |
Appears in Collections: | Aurora harvest 8 Molecular and Biomedical Science publications |
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hdl_106762.pdf | Published Version | 2.75 MB | Adobe PDF | View/Open |
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