Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/120719
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Population data provide evidence against the presence of a set point for hemoglobin levels or tissue oxygen delivery
Author: Fitzgerald, S.P.
Grote Beverborg, N.
Beguin, Y.
Artunc, F.
Falhammar, H.
Bean, N.G.
Citation: Physiological Reports, 2019; 7(12):e14153-1-e14153-10
Publisher: Wiley
Issue Date: 2019
ISSN: 2051-817X
2051-817X
Statement of
Responsibility: 
Stephen P. Fitzgerald, Niels Grote Beverborg, Yves Beguin, Ferruh Artunc, Henrik Falhammar, Nigel G. Bean
Abstract: Hemoglobin levels are believed to be regulated as per a set point model of regulation. This model of regulation, by which specific levels of a parameter are targeted and defended by physiological systems, implies a particular population correlation between the parameter and its controlling hormone. Empirical population correlations of other parameters and their controlling hormones, have denied the presence of such set point-based regulation. To assess if hemoglobin is regulated according to a set point model we performed a systematic search of PubMed/MEDLINE and Web of Science identifying relevant reports published up to November 2018. Population hemoglobin/erythropoietin level correlations were retrieved, and these empirically derived correlations were compared with the positive correlation implied by a set point model of regulation. Authors of papers containing potentially suitable data were contacted with requests for further analyses, and a meta-analysis was performed. Twelve correlations between hemoglobin and erythropoietin levels from eleven papers were analyzed. None of these correlations were significantly positive, three, restricted to the normal range of hemoglobin, were significantly negative. All but one of the other correlations showed a negative trend. New analyses of previously published data sets resulted in similar findings. In particular a new analysis of large data sets of males (n = 2417) and females (n = 2592) with normal range hemoglobin levels, revealed significantly negative correlations. A meta-analysis of our results indicated that the data overall are not consistent with a positive relationship between hemoglobin and erythropoietin (P < 0.0001). Population data indicate that individuals do not have set point levels of hemoglobin.
Keywords: Erythropoietin; haemoglobin; population correlations; set point
Rights: © 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
DOI: 10.14814/phy2.14153
Published version: http://dx.doi.org/10.14814/phy2.14153
Appears in Collections:Aurora harvest 8
Medicine publications

Files in This Item:
File Description SizeFormat 
hdl_120719.pdfPublished Version386.14 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.