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https://hdl.handle.net/2440/129041
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Type: | Journal article |
Title: | Meroterpenoid natural products from streptomyces bacteria - the evolution of chemoenzymatic syntheses |
Author: | Murray, L.A.M. McKinnie, S.M.K. Moore, B.S. George, J.H. |
Citation: | Natural Product Reports: a journal of current development in bioorganic chemistry, 2020; 37(1):1-33 |
Publisher: | Royal Society of Chemistry |
Issue Date: | 2020 |
ISSN: | 0265-0568 1460-4752 |
Statement of Responsibility: | Lauren A. M. Murray, Shaun M. K. McKinnie, Bradley S. Moore and Jonathan H. George |
Abstract: | Covering: Up to January 2020Meroterpenoids derived from the polyketide 1,3,6,8-tetrahydroxynaphthalene (THN) are complex natural products produced exclusively by Streptomyces bacteria. These antibacterial compounds include the napyradiomycins, merochlorins, marinones, and furaquinocins and have inspired many attempts at their chemical synthesis. In this review, we highlight the role played by biosynthetic studies in the stimulation of biomimetic and, ultimately, chemoenzymatic total syntheses of these natural products. In particular, the application of genome mining techniques to marine Streptomyces bacteria led to the discovery of unique prenyltransferase and vanadium-dependent haloperoxidase enzymes that can be used as highly selective biocatalysts in fully enzymatic total syntheses, thus overcoming the limitations of purely chemical reagents. |
Keywords: | Streptomyces Terpenes Naphthoquinones Enzymes Biological Products Anti-Bacterial Agents Molecular Structure |
Rights: | This journal is © The Royal Society of Chemistry 2020 |
DOI: | 10.1039/d0np00018c |
Grant ID: | http://purl.org/au-research/grants/arc/FT170100437 |
Published version: | http://dx.doi.org/10.1039/d0np00018c |
Appears in Collections: | Aurora harvest 8 Physics publications |
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