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https://hdl.handle.net/2440/130573
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Type: | Journal article |
Title: | Modeling motor-evoked potentials from neural field simulations of transcranial magnetic stimulation |
Author: | Wilson, M.T. Moezzi, B. Rogasch, N.C. |
Citation: | Clinical Neurophysiology, 2021; 132(2):412-428 |
Publisher: | Elsevier |
Issue Date: | 2021 |
ISSN: | 1388-2457 1872-8952 |
Statement of Responsibility: | Marcus T.Wilson, Bahar Moezzi, Nigel C.Rogasch |
Abstract: | Objective To develop a population-based biophysical model of motor-evoked potentials (MEPs) following transcranial magnetic stimulation (TMS).<h4>Methods</h4>We combined an existing MEP model with population-based cortical modeling. Layer 2/3 excitatory and inhibitory neural populations, modeled with neural-field theory, are stimulated with TMS and feed layer 5 corticospinal neurons, which also couple directly but weakly to the TMS pulse. The layer 5 output controls mean motoneuron responses, which generate a series of single motor-unit action potentials that are summed to estimate a MEP. Results A MEP waveform was generated comparable to those observed experimentally. The model captured TMS phenomena including a sigmoidal input-output curve, common paired pulse effects (short interval intracortical inhibition, intracortical facilitation, long interval intracortical inhibition) including responses to pharmacological interventions, and a cortical silent period. Changes in MEP amplitude following theta burst paradigms were observed including variability in outcome direction. Conclusions The model reproduces effects seen in common TMS paradigms.<h4>Significance</h4>The model allows population-based modeling of changes in cortical dynamics due to TMS protocols to be assessed in terms of changes in MEPs, thus allowing a clear comparison between population-based modeling predictions and typical experimental outcome measures. |
Keywords: | Calcium dependent plasticity Cortical plasticity Corticomotor system MEP Modeling Motor evoked potential Neural field theory Paired-pulse TMS Theta burst stimulation Transcranial magnetic stimulation cTBS iTBS rTMS |
Rights: | © 2020 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved. |
DOI: | 10.1016/j.clinph.2020.10.032 |
Grant ID: | http://purl.org/au-research/grants/arc/DE180100741 |
Published version: | http://dx.doi.org/10.1016/j.clinph.2020.10.032 |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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