Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/3051
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Immunizations with pneumococcal surface protein A and pneumolysin are protective against pneumonia in a murine model of pulmonary infection with Streptococcus pneumoniae |
Author: | Briles, D. Hollingshead, S. Paton, J. Ades, E. Novak, L. van Ginkel, F. Benjamin Jr, W. |
Citation: | Journal of Infectious Diseases, 2003; 188(3):339-348 |
Publisher: | Univ Chicago Press |
Issue Date: | 2003 |
ISSN: | 0022-1899 1537-6613 |
Statement of Responsibility: | David E. Briles, Susan K. Hollingshead, James C. Paton, Edwin W. Ades, Lea Novak, Frederik W. van Ginkel, and William H. Benjamin, Jr. |
Abstract: | Intranasal infection of mice with certain strains of capsular group 19 Streptococcus pneumoniae can result in focal pneumonia in the absence of bacteremia. Using this model of murine pneumonia, we demonstrated that immunization with recombinant forms of either pneumococcal surface protein A (PspA) or PdB (a genetically detoxified derivative of pneumolysin) elicited significant protection against focal pulmonary infection. This may be the first demonstration that a proposed vaccine antigen can protect against pneumococcal pneumonia. The best protection was obtained by immunizing mice with a mixture of PspA and PdB, indicating that the protection elicited by these antigens can complement each other. This result is in agreement with previous studies that used pneumococcal sepsis and nasal colonization models and demonstrate that the best protein vaccines for prevention of infection may be those that include more than one protection-eliciting pneumococcal protein. |
Keywords: | Lung Animals Mice, Inbred CBA Mice Streptococcus pneumoniae Pneumonia, Pneumococcal Focal Infection Disease Models, Animal Bacterial Proteins Recombinant Proteins Vaccines, Synthetic Streptolysins Pneumococcal Vaccines Vaccines, Combined Antigens, Bacterial Immunization Administration, Intranasal Female |
Rights: | © 2003 by the Infectious Diseases Society of America. All rights reserved. |
DOI: | 10.1086/376571 |
Published version: | http://dx.doi.org/10.1086/376571 |
Appears in Collections: | Aurora harvest 2 Molecular and Biomedical Science publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
hdl_1351.pdf | 382.26 kB | Publisher's PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.