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https://hdl.handle.net/2440/56132
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Type: | Journal article |
Title: | Comparison of stem-cell-mediated osteogenesis and dentinogenesis |
Author: | Batouli, S. Miura, M. Brahim, J. Tsutsui, T. Fisher, L. Gronthos, S. Robey, P. Shi, S. |
Citation: | Journal of Dental Research, 2003; 82(12):976-981 |
Publisher: | Inter Amer Assoc Dental Research |
Issue Date: | 2003 |
ISSN: | 0022-0345 1544-0591 |
Statement of Responsibility: | S. Batouli, M. Miura, J. Brahim, T.W. Tsutsui, L.W. Fisher, S. Gronthos, P. Gehron Robey and S. Shi |
Abstract: | The difference between stem-cell-mediated bone and dentin regeneration is not yet well-understood. Here we use an in vivo stem cell transplantation system to investigate differential regulation mechanisms of bone marrow stromal stem cells (BMSSCs) and dental pulp stem cells (DPSCs). Elevated expression of basic fibroblast growth factor (bFGF) and matrix metalloproteinase 9 (MMP-9, gelatinase B) was found to be associated with the formation of hematopoietic marrow in BMSSC transplants, but not in the connective tissue of DPSC transplants. The expression of dentin sialoprotein (DSP) specifically marked dentin synthesis in DPSC transplants. Moreover, DPSCs were found to be able to generate reparative dentin-like tissue on the surface of human dentin in vivo. This study provided direct evidence to suggest that osteogenesis and dentinogenesis mediated by BMSSCs and DPSCs, respectively, may be regulated by distinct mechanisms, leading to the different organization of the mineralized and non-mineralized tissues. |
Keywords: | bone marrow stromal stem cell dental pulp stem cell osteoblast odontoblast transplantation |
DOI: | 10.1177/154405910308201208 |
Published version: | http://dx.doi.org/10.1177/154405910308201208 |
Appears in Collections: | Aurora harvest Medicine publications |
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