Adelaide Research & Scholarship
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https://hdl.handle.net/2440/66273
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| Type: | Journal article |
| Title: | Transcriptional interference by RNA polymerase pausing and dislodgement of transcription factors |
| Author: | Palmer, A. Egan, J. Shearwin, K. |
| Citation: | Transcription, 2011; 2(1):9-14 |
| Publisher: | Landes Bioscience |
| Issue Date: | 2011 |
| ISSN: | 2154-1264 2154-1272 |
| Statement of Responsibility: | Adam C. Palmer, J. Barry Egan and Keith E. Shearwin |
| Abstract: | Transcriptional interference is the in cis suppression of one transcriptional process by another. Mathematical modeling shows that promoter occlusion by elongating RNA polymerases cannot produce strong interference. Interference may instead be generated by (1) dislodgement of slow-to-assemble pre-initiation complexes and transcription factors and (2) prolonged occlusion by paused RNA polymerases. |
| Keywords: | transcriptional interference tandem promoters RNAP pausing gene regulation dislodgement TRCF transcription factor |
| Rights: | © 2011 Landes Bioscience |
| DOI: | 10.4161/trns.2.1.13511 |
| Published version: | http://dx.doi.org/10.4161/trns.2.1.13511 |
| Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
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