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https://hdl.handle.net/2440/73370
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Type: | Journal article |
Title: | Synergistic effect of 14-alpha-lipoyl andrographolide and various antibiotics on the formation of biofilms and production of exopolysaccharide and pyocyanin by Pseudomonas aeruginosa |
Author: | Zeng, X. Liu, X. Bian, J. Pei, G. Dai, H. Polyak, S. Song, F. Ma, L. Wang, Y. Zhang, L. |
Citation: | Antimicrobial Agents and Chemotherapy, 2011; 55(6):3015-3017 |
Publisher: | Amer Soc Microbiology |
Issue Date: | 2011 |
ISSN: | 0066-4804 1098-6596 |
Statement of Responsibility: | Xiangping Zeng, Xiangyang Liu, Jiang Bian, Gang Pei, Huanqin Dai, Steven W. Polyak, Fuhang Song, Li Ma, Yuqiang Wang, and Lixin Zhang |
Abstract: | Pseudomonas aeruginosa produces a biofilm that provides the bacteria with an effective barrier against antibiotics. Here, we investigated the synergy of various antibiotics with 14-alpha-lipoyl andrographolide (AL-1), focusing upon synthesis of the biofilm. AL-1 also inhibited the production of the exopolysaccharide and pyocyanin components. We propose that AL-1 may potentially serve as a cotherapy to combat P. aeruginosa. |
Keywords: | Biofilms Pseudomonas aeruginosa Diterpenes Pyocyanine Polysaccharides, Bacterial Anti-Bacterial Agents Quorum Sensing |
Rights: | Copyright © 2011, American Society for Microbiology. All Rights Reserved. |
DOI: | 10.1128/AAC.00575-10 |
Published version: | http://dx.doi.org/10.1128/aac.00575-10 |
Appears in Collections: | Aurora harvest 5 Molecular and Biomedical Science publications |
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