Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/7555
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Repeated dose inhaled budesonide versus placebo in the treatment of croup |
Author: | Roberts, G. Master, V. Staugas, R. Raftos, J. Parsons, D. Coulthard, K. Martin, A. |
Citation: | Journal of Paediatrics and Child Health, 1999; 35(2):170-174 |
Publisher: | Blackwell Science |
Issue Date: | 1999 |
ISSN: | 1034-4810 1440-1754 |
Statement of Responsibility: | GW Roberts, VV Master, RE Staugas, JV Raftos, DW Parsons, KP Coulthard and AJ Martin |
Abstract: | Objective: To investigate the efficacy and tolerance of 12-hourly dosing with 2 mg 4 mL–1 of inhaled budesonide versus placebo in patients admitted to hospital with moderate/severe croup. Method: Eighty-two children hospitalised with croup received either 2 mg 4 mL–1 of budesonide or placebo 12 hourly (maximum four doses) via Ventstream® nebuliser in a randomised, double-blind manner. Croup scores were performed at 0, 2, 6, 12, 24, 36 and 48 h from initial nebulisation whilst the patient remained hospitalised. Follow-up assessments were made 1 and 3 days after discharge. Results: Improvement was observed in the budesonide group over the 12-h dosing interval when compared to placebo (P = 0.04). Time to attain a significant clinical improvement was superior in the budesonide group (P = 0.01). Three days after discharge seven of 32 placebo-treated patients and one of 34 budesonide-treated patients had sought further medical follow-up (P = 0.02). Conclusion: Twelve-hourly dosing with inhaled budesonide significantly improved symptoms of croup as well as decreased relapse rates when compared with placebo. |
Keywords: | budesonide croup inhalation relapse |
DOI: | 10.1046/j.1440-1754.1999.t01-1-00335.x |
Published version: | http://dx.doi.org/10.1046/j.1440-1754.1999.t01-1-00335.x |
Appears in Collections: | Aurora harvest Paediatrics publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.