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https://hdl.handle.net/2440/76007
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Type: | Journal article |
Title: | The dengue virus M protein localises to the endoplasmic reticulum and forms oligomers |
Author: | Wong, S. Haqshenas, G. Gowans, E. MacKenzie, J. |
Citation: | FEBS Letters, 2012; 586(7):1032-1037 |
Publisher: | Elsevier Science BV |
Issue Date: | 2012 |
ISSN: | 0014-5793 1873-3468 |
Statement of Responsibility: | Sook-San Wonga, Gholamreza Haqshenas, Eric J. Gowans, Jason Mackenzie |
Abstract: | The dengue virus membrane (M) protein is a key component of the mature virion. Here, we characterised the cellular behaviour of M using a recombinant protein construct to understand its inherent properties. Using confocal microscopy, we showed that M and its intracellular precursor, prM, localised to the endoplasmic reticulum. M protein was also detected on the cell surface and secreted, suggesting that M can enter the secretory pathway. In addition, cross-linking studies showed that M can form dimers and tetramers. These findings suggest that M behaves as a secretory protein analogous to the major envelope protein E. |
Keywords: | Dengue PrM M Protein Localisation Endoplasmic reticulum Oligomerisation |
Rights: | Crown Copyright © 2012 Published by Elsevier B.V. on behalf of Federation of European Biochemical society. All rights reserved. |
DOI: | 10.1016/j.febslet.2012.02.047 |
Published version: | http://dx.doi.org/10.1016/j.febslet.2012.02.047 |
Appears in Collections: | Aurora harvest 4 Surgery publications |
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