Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/76770
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | QT interval variability in type 2 diabetic patients with cardiac sympathetic dysinnervation assessed by ¹²³I-metaiodobenzylguanidine scintigraphy |
Other Titles: | QT interval variability in type 2 diabetic patients with cardiac sympathetic dysinnervation assessed by (123)I-metaiodobenzylguanidine scintigraphy |
Author: | Sacre, J. Franjic, B. Coombes, J. Marwick, T. Baumert, M. |
Citation: | Journal of Cardiovascular Electrophysiology, 2013; 24(3):305-313 |
Publisher: | Futura Publ Co |
Issue Date: | 2013 |
ISSN: | 1045-3873 1540-8167 |
Statement of Responsibility: | Julian W. Sacre, Bennett Franjic, Jeff S. Coombes, Thomas H. Marwick, and Mathias Baumert |
Abstract: | Introduction: The mechanism of adverse prognosis attributable to proarrhythmic cardiac sympathetic dysinnervation in patients with type 2 diabetes is incompletely understood. This study sought the association of cardiac sympathetic dysinnervation with temporal instability of ventricular repolarization assessed by beat-to-beat QT interval variability. Methods and Results: 123I-metaiodobenzylguanidine (123I-MIBG) scintigraphy was analyzed in 31 type 2 diabetic patients for cardiac sympathetic dysinnervation (4-hour heart-to-mediastinum ratio <1.8) and regional sympathetic integrity and washout rate (from 15-minute 123I-MIBG uptake). Relative QT variability was defined from a continuous 5-minute ECG in the supine position (n = 31) and standing position (subgroup; n = 15) by the log ratio of absolute QT variability (QT variance divided by the mean QT interval squared) to heart rate (HR) variability (HR variance divided by the mean HR squared). Patients with (n = 16; 52%) versus without cardiac sympathetic dysinnervation demonstrated higher relative QT variability in the supine position (P < 0.001), owing to lower HR variability. However, on standing, absolute QT variability was significantly raised in these patients (P = 0.009) despite similar HR variability in the 2 groups. Correlations of heart-to-mediastinum ratio with standing QT variability (relative [r=−0.63, P = 0.013] and absolute [r=−0.79, P = 0.001]) were superior to corresponding supine measures (relative [r = −0.47, P = 0.008] and absolute [P = NS]). No associations of QT variability with washout rate or regional 123I-MIBG uptake were identified. Conclusion: Elevated QT variability is associated with cardiac sympathetic dysinnervation in type 2 diabetes and may contribute to adverse prognosis. Moreover, QT variability may be more specific for cardiac sympathetic innervation when measured in the context of sympathetic activation. |
Keywords: | Autonomic nervous system diabetic autonomic neuropathy diabetes mellitus meta-iodobenzylguanidine QT interval radionuclide imaging |
Rights: | © 2012 Wiley Periodicals, Inc. |
DOI: | 10.1111/jce.12039 |
Grant ID: | ARC |
Published version: | http://dx.doi.org/10.1111/jce.12039 |
Appears in Collections: | Aurora harvest Electrical and Electronic Engineering publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.