Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/79040
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Immunospecific targeting of CD45 expressing lymphoid cells: Towards improved detection agents of the sentinel lymph node |
Author: | Liu, T. Cousins, A. Chien, C. Kempson, I. Thompson, S. Hwu, Y. Thierry, B. |
Citation: | Cancer Letters, 2013; 328(2):271-277 |
Publisher: | Elsevier Sci Ireland Ltd |
Issue Date: | 2013 |
ISSN: | 0304-3835 1872-7980 |
Statement of Responsibility: | Tianqing Liu, Aidan Cousins, Chia-Chi Chien, Ivan Kempson, Sarah Thompson, Yeukuang Hwu, Benjamin Thierry |
Abstract: | This study was designed to demonstrate the potential of small nanoparticulate lymphotropic contrast agents designed to bind with high affinity to lymphoid cells overexpressing the CD45 antigen. To this end, small gold nanoparticles used as model were conjugated to anti-CD45 antibodies and injected in mice in the dorsal toe of the fore/hind paw. Chemical analysis demonstrated rapid uptake and transport of the nanoparticles in the lymphatic as well as significant retention of the nanoparticles with high binding affinity to lymphoid cells in the popliteal and axillary lymph nodes in comparison to non-targeted nanoparticles. |
Keywords: | Anti-CD45 immunotargeting Lymphatic transport Gold nanoparticles Sentinel lymph node |
Rights: | © 2012 Elsevier Ireland Ltd. All rights reserved. |
DOI: | 10.1016/j.canlet.2012.09.024 |
Published version: | http://dx.doi.org/10.1016/j.canlet.2012.09.024 |
Appears in Collections: | Aurora harvest Surgery publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
hdl_79040.pdf | Accepted version | 544.55 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.