Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/8705
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Mobilization of predominantly Philadelphia chromosome-negative blood progenitors using cyclophosphamide and rHUG-CSF in early chronic-phase chronic myeloid leukaemia: correlation with Sokal prognostic index and haematological control. |
Author: | Hughes, T. Grigg, A. Szer, J. Ho, J. Ma, D. Dale, B. Green, R. Norman, J. Sage, R. Herrmann, R. Cannell, P. Schwarer, A. Taylor, K. Atkinson, K. Arthur, C. |
Citation: | British Journal of Haematology, 1997; 96(3):635-640 |
Publisher: | Blackwell Publishing |
Issue Date: | 1997 |
ISSN: | 0007-1048 1365-2141 |
Abstract: | Mobilization of Philadelphia chromosome (Ph) negative blood progenitors was attempted in 23 newly diagnosed chronic myeloid leukaemia (CML) patients using a regimen of cyclophosphamide (CY) 5 g/m² and rHUG-CSF 150 μg/m² daily. This regimen was well tolerated with no major adverse events reported. More than 2 × 10⁶/kg CD34⁺ cells were collected in 21 patients (91%). Predominantly Ph-negative mobilization (0–25% Ph-positive) was seen in 30% of cases overall and was confined to patients with a Sokal prognostic score < 1 (7/11 with Sokal score <1; 0/12 with Sokal score ≥1). Within the low Sokal index group, a low WBC count pre-mobilization and a low WBC nadir both correlated strongly with Ph-negative mobilization (P =0.006 and 0.02 respectively). Five of 19 patients receiving at least 6 months of Roferon A therapy post mobilization achieved a major cytogenetic response; all five patients were Ph-negative mobilizers. Therefore CML patients can be divided into a good-prognosis group in whom predominantly Ph-negative progenitors can be mobilized using a regimen of moderate intensity if haematological control is achieved pre-mobilization, and a poor-prognosis group for whom predominantly Ph-positive cells are mobilized with this regimen regardless of haematological control. |
Keywords: | Hematopoietic Stem Cells Humans Leukemia, Myeloid, Chronic-Phase Cyclophosphamide Granulocyte Colony-Stimulating Factor Interferon-alpha Prognosis Treatment Outcome Leukapheresis Hematopoietic Stem Cell Transplantation Transplantation, Autologous Adult Aged Middle Aged Female Male |
DOI: | 10.1046/j.1365-2141.1997.d01-2068.x |
Published version: | http://www3.interscience.wiley.com/journal/119164513/abstract |
Appears in Collections: | Aurora harvest 4 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.