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https://hdl.handle.net/2440/87533
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Type: | Journal article |
Title: | Cell-cell communication between malaria-infected red blood cells via exosome-like vesicles |
Author: | Regev-Rudzki, N. Wilson, D. Carvalho, T. Sisquella, X. Coleman, B. Rug, M. Bursac, D. Angrisano, F. Gee, M. Hill, A. Baum, J. Cowman, A. |
Citation: | Cell, 2013; 153(5):1120-1133 |
Publisher: | Elsevier |
Issue Date: | 2013 |
ISSN: | 0092-8674 1097-4172 |
Statement of Responsibility: | Neta Regev-Rudzki, Danny W. Wilson, Teresa G. Carvalho, Xavier Sisquella, Bradley M. Coleman, Melanie Rug, Dejan Bursac, Fiona Angrisano, Michelle Gee, Andrew F. Hill, Jake Baum, Alan F. Cowman |
Abstract: | Cell-cell communication is an important mechanism for information exchange promoting cell survival for the control of features such as population density and differentiation. We determined that Plasmodium falciparum-infected red blood cells directly communicate between parasites within a population using exosome-like vesicles that are capable of delivering genes. Importantly, communication via exosome-like vesicles promotes differentiation to sexual forms at a rate that suggests that signaling is involved. Furthermore, we have identified a P. falciparum protein, PfPTP2, that plays a key role in efficient communication. This study reveals a previously unidentified pathway of P. falciparum biology critical for survival in the host and transmission to mosquitoes. This identifies a pathway for the development of agents to block parasite transmission from the human host to the mosquito. |
Keywords: | Erythrocytes Microtubules Animals Humans Culicidae Plasmodium falciparum Malaria, Falciparum Actins Cell Communication Signal Transduction Drug Resistance Plasmids Trophozoites Exosomes |
Rights: | © 2013 Elsevier Inc. |
DOI: | 10.1016/j.cell.2013.04.029 |
Published version: | http://dx.doi.org/10.1016/j.cell.2013.04.029 |
Appears in Collections: | Aurora harvest 2 Molecular and Biomedical Science publications |
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